原著論文/Original Papers

山中 章弘

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2006年以前

Xie X, Crowder TL, Yamanaka A, Morairty SR, Lewinter RD, Sakurai T, Kilduff TS
GABA(B) receptor-mediated modulation of hypocretin/orexin neurones in mouse hypothalamus. J Physiol 574: 399-414 (2006).
*Yamanaka A, Muraki Y, Ichiki K, Tsujino N, Kilduff TS, Goto K, Sakurai T
Orexin neurons are directly and indirectly regulated by catecholamines in a complex manner. J Neurophysiol 96: 284-298 (2006).
(日本語内容解説)
Toshinai K, Yamaguchi H, Sun Y, Smith RG, Yamanaka A, Sakurai T, Date Y, Mondal MS, Shimbara T, Kawagoe T, Murakami N, Miyazato M, Kangawa K, Nakazato M
Des-acyl ghrelin induces food intake by a mechanism independent of the growth hormone secretagogue receptor. Endocrinology 147: 2306-2314 (2006).
Takayasu S, Sakurai T, Iwasaki S, Teranishi H, Yamanaka A, Williams SC, Iguchi H, Kawasawa YI, Ikeda Y, Sakakibara I, Ohno K, Ioka RX, Murakami S, Dohmae N, Xie J, Suda T, Motoike T, Ohuchi T, Yanagisawa M, Sakai J
A neuropeptide ligand of the G protein-coupled receptor GPR103 regulates feeding, behavioral arousal and blood pressure in mice. Proc Natl Acad Sci U S A 103: 7438-7443 (2006).
Obara K, Uchino M, Koide M, Yamanaka A, Nakayama K
Stretch-induced triphosphorylation of myosin light chain and myogenic tone in canine basilar artery. Eur J Pharmacol 534: 141-151 (2006).
Tsujino N, *Yamanaka A, Ichiki K, Muraki Y, Kilduff TS, Yagami K, Takahashi S, Goto K, Sakurai T
Cholecystokinin activates orexin/hypocretin neurons through the cholecystokinin A receptor. J Neurosci 25: 7459-7469 (2005).
(日本語内容解説)
Sakurai T, Nagata R, Yamanaka A, Kawamura H, Tsujino N, Muraki Y, Kageyama H, Kunita S, Takahashi S, Goto K, Koyama Y, Shioda S, Yanagisawa M
Input of orexin/hypocretin neurons revealed by a genetically encoded tracer in mice. Neuron 46: 297-308 (2005).
(日本語内容解説)
Winsky-Sommerer R, Yamanaka A, Diano S, Borok E, Roberts AJ, Sakurai T, Kilduff TS, Horvath TL, de Lecea L
Interaction between the corticotropin-releasing factor system and hypocretins (orexins): a novel circuit mediating stress response.         J Neurosci 24: 11439-11448 (2004).
Muraki Y, *Yamanaka A, Tsujino N, Kilduff TS, Goto K, Sakurai T
Serotonergic regulation of the orexin/hypocretin neurons through the 5-HT1A receptor. J Neurosci 24: 7159-7166 (2004).
(日本語内容解説)
Muroya S, Funahashi H, Yamanaka A, Kohno D, Uramura K, Nambu T, Shibahara M, Kuramochi M, Takigawa M, Yanagisawa M, Sakurai T, Shioda S, Yada T
Orexins (hypocretins) directly interact with neuropeptide Y, POMC and glucose-responsive neurons to regulate Ca 2+ signaling in a reciprocal manner to leptin: orexigenic neuronal pathways in the mediobasal hypothalamus. Eur J Neurosci 19: 1524-1534 (2004).
Zhu Y, Miwa Y, Yamanaka A, Yada T, Shibahara M, Abe Y, Sakurai T, Goto K
Orexin receptor type-1 couples exclusively to pertussis toxin-insensitive G-proteins, while orexin receptor type-2 couples to both pertussis toxin-sensitive and -insensitive G-proteins. J Pharmacol Sci 92: 259-266 (2003).
Yamanaka A, Beuckmann CT, Willie JT, Hara J, Tsujino N, Mieda M, Tominaga M, Yagami K, Sugiyama F, Goto K, Yanagisawa M, Sakurai T
Hypothalamic orexin neurons regulate arousal according to energy balance in mice. Neuron 38: 701-713 (2003).
(日本語内容解説)
Tanaka H, Yoshida T, Miyamoto N, Motoike T, Kurosu H, Shibata K, Yamanaka A, Williams SC, Richardson JA, Tsujino N, Garry MG, Lerner MR, King DS, O'Dowd BF, Sakurai T, Yanagisawa M
Characterization of a family of endogenous neuropeptide ligands for the G protein-coupled receptors. Proc Natl Acad Sci U S A 100: 6251-6256 (2003).
Yamanaka A, Muraki Y, Tsujino N, Goto K, Sakurai T
Regulation of orexin neurons by the monoaminergic and cholinergic systems. Biochem Biophys Res Commun 303: 120-129 (2003).
(日本語内容解説)
Zhu Y, Yamanaka A, Kunii K, Tsujino N, Goto K, Sakurai T
Orexin-mediated feeding behavior involves both leptin-sensitive and -insensitive pathways. Physiol Behav 77: 251-257 (2002).
Nanmoku T, Isobe K, Sakurai T, Yamanaka A, Takekoshi K, Kawakami Y, Goto K, Nakai T
Effects of orexin on cultured porcine adrenal medullary and cortex cells. Regul Pept 104: 125-130 (2002).
Yamanaka A, Tsujino N, Funahashi H, Honda K, Guan JL, Wang QP, Tominaga M, Goto K, Shioda S, Sakurai T
Orexins activate histaminergic neurons via the orexin 2 receptor. Biochem Biophys Res Commun 290: 1237-1245 (2002).
(日本語内容解説)
Obara K, Saito M, Yamanaka A, Uchino M, Nakayama K
Involvement of different activator Ca(2+) in the rate-dependent stretch-induced contractions of canine basilar artery. Jpn J Physiol 51: 327-335 (2001).
Yamada M, Miyakawa T, Duttaroy A, Yamanaka A, Moriguchi T, Makita R, Ogawa M, Chou CJ, Xia B, Crawley JN, Felder CC, Deng CX, Wess J
Mice lacking the M3 muscarinic acetylcholine receptor are hypophagic and lean. Nature 410: 207-212 (2001).
Nanmoku T, Isobe K, Sakurai T, Yamanaka A, Takekoshi K, Kawakami Y, Ishii K, Goto K, Nakai T
Orexins suppress catecholamine synthesis and secretion in cultured PC12 cells. Biochem Biophys Res Commun 274: 310-315 (2000).
Abe Y, Nakayama K, Yamanaka A, Sakurai T, Goto K
Subtype-specific trafficking of endothelin receptors. J Biol Chem 275: 8664-8671 (2000).
Yamanaka A, Kunii K, Nambu T, Tsujino N, Sakai A, Matsuzaki I, Miwa Y, Goto K, Sakurai T
Orexin-induced food intake involves neuropeptide Y pathway. Brain Res 859: 404-409 (2000).
Yamanaka A, Sakurai T, Katsumoto T, Yanagisawa M, Goto K
Chronic intracerebroventricular administration of orexin-A to rats increases foodintake in daytime, but has no effect on body weight. Brain Res 849: 248-252 (1999).
Kunii K, Yamanaka A, Nambu T, Matsuzaki I, Goto K, Sakurai T
Orexins/hypocretins regulate drinking behaviour.  Brain Res 842: 256-261 (1999).
Yamanaka A, Ishikawa T, Goto K
Characterization of endothelium-dependent relaxation independent of NO and prostaglandins in guinea pig coronary artery. J Pharmacol Exp Ther 285: 480-489 (1998).
Yamada M, Ishikawa T, Yamanaka A, Fujimori A, Goto K
Local neurogenic regulation of rat hindlimb circulation: CO2-induced release of calcitoningene-related peptide from sensory nerves. Br J Pharmacol 122: 710-4 (1997).