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Koji Yamanaka Lab.

Department of Neuroscience and Pathobiology, RIEM, Nagoya University

Introduction

This laboratory has started since 2013. Our mission is to uncover the mechanisms of neurodegenerative disorder, motor neuron disease, to develop the viable therapy.

Nishino and Yamanaka

Nov. 17, 2017: Mr. Nishino get a Medical Student Research Award of Nagoya University 2017.

An extension lecuture

Oct. 21, 2017: We held an extention lecuture of RIEM 2017 entitled as "Efforts to overcome neurodegenerative diseases".

group photo 2017

Apr. 2017: New members joined our laboratory.

MAM disruption

Nov. 2016: We reported the role of MAM disruption in ALS.
(Watanabe et al. EMBO Molecular Medicine)

Our Recent Activities

2017/11/22

Prof. Yamanaka gave presentations in the symposium or meeting listed below:

  • 9/7 60th Anuual Meeting of the Japanese Society for Neurochemistry (Sendai, Japan)
  • 9/19 23rd World Congress of Neurology (WCN) (with 58th Annual Meeting of the Japanese Society of Neurology) (Kyoto, Japan)
    Mr. Nishino also gave his presentation in theis meeting.
  • 9/28 47th Annual Meeting of the Japanese Society of Neuropsychopharmacology (with 39th Annual Meeting of the Japanese Society of Biological Psychiatry) (Sapporo, Japan)
  • 10/6 29th Annual Meeting of the Japanese Society for Neurochemistry (Sapporo, Japan)

2017/11/17

Mr. Nishino won a Medical Student Research Award of Nagoya University 2017.

Nihsino and Yamanaka

2017/11/9

Our collaborative work with Nagoya City University (Drs. Tsuiji & Hattori) is now in press in Scientific Reports:

We analysed age-dependent changes in TDP-43 transgenic mice, and found the accumulation of abundant poly-ubiquitinated, interneuron-specific protein aggregates in the hippocampus of the aged mice. Our results indicate that interneuron degeneration, which occurs upon aging, may be related to the impaired memory of TDP-43 transgenic mice.

Open Access
Tsuiji H, Inoue I, Takeuchi M, Furuya A, Yamakage Y, Watanabe S, Koike M, Hattori M, Yamanaka K
link to other site TDP-43 accelerates age-dependent degeneration of interneurons.
Scientific Reports 7: 14972, 2017.

link to other site Prese release from Nagoya University

2017/10/23

We held an extention lecuture of RIEM 2017 entitled as "Efforts to overcome neurodegenerative diseases".

A large number of audience came to our lecuture in spite of bad weather, a typhoon.
The lecturers presented interesting and useful information about research/nursing on neurodegenrative diseases such as ALS.
We deeply thank all the lectures for their great presentation, and also thank all the audience.

Lecturers Scence in the discussion Presentation by Prof. Yamanaka

(1st) Group photo of the lecuturers. Drs. Ikuko Aiba (Higashi-Nagoya National Hospital), Yasumasa Kokubo (Mie Univ.), Hideyuki Okano (Keio Univ.), and Koji Yamanaka (Nagoya Univ.) from the left.
(2nd) A scene in the discussion.
(3rd) A scene in the lecuture by Dr. Yamanaka.

2017/10/2

Mr. Kidou & Mr. Inami joined our laboratory. See our members page.

2017/6/1

Ms. Matsuoka joined our laboratory.

2017/4/27

Members page was up-dated.

2017/1/25

Our collaborative works are now in press:

Open Access
Morisaki Y, Niikura M, Watanabe M, Onishi K, Tanabe S, Moriwaki Y, Okuda T, Ohara S, Murayama S, Takao M, Uchida S, Yamanaka K, Misawa H.
Selective Expression of Osteopontin in ALS-resistant Motor Neurons is a Critical Determinant of Late Phase Neurodegeneration Mediated by Matrix Metalloproteinase-9.
Scientific Reports 6: 27354, 2016.

Amanullah A, Upadhyay A, Chhangani D, Joshi V, Mishra R, Yamanaka K, Mishra A.
Proteasomal Dysfunction Induced by Diclofenac Engenders Apoptosis Through Mitochondrial Pathway.
Journal of Cellular Biochemistry 2016, Epub ahead of print.

Anzai I, Tokuda E, Mukaiyama A, Akiyama S, Endo F, Yamanaka K, Misawa H, Furukawa Y.
A misfolded dimer of Cu/Zn-superoxide dismutase leading to pathological oligomerization in amyotrophic lateral sclerosis.
Protein Science 2016, in press.

Open Access
Tokuda E, Anzai I, Nomura T, Toichi K, Watanabe M, Ohara S, Watanabe S, Yamanaka K, Morisaki Y, Misawa H, Furukawa Y.
Immunochemical characterization on pathological oligomers of mutant Cu/Zn-superoxide dismutase in amyotrophic lateral sclerosis.
Molecular Neurodegeneration 12:2, 2017.

2017/12/9

Prof. Yamanaka & Dr. Watanabe gave presentations in the 28th International Symposium on ALS/MND:

2016/12/7(Wed)-9(Fri) at Dublin, Ireland

2017/11/11

Prof. Yamanaka gave an ivited talk in the 2nd IMCR Symposium on Endocrine and Metabolism:International Frontiers in Homeostatic Regulation Research:

at Tojo Hall, Gunma University

2017/11/1

Dr. Jin leaved for US, and Ms. Higuchi joined us as a technical staff.

2016/11/7

Our paper is now in press in EMBO Molecular Medicine:

MAM disruption

Mitochondria-associated membrane (MAM) is a contacting site of endoplasmic reticulum and mitochondria, and plays a key role in cellular homeostasis. We identified that disruption of the MAM is tightly involved in the pathology of amyotrophic lateral sclerosis (ALS).

Open Access
Watanabe S, Ilieva H, Tamada H, Nomura H, Komine O, Endo F, Jin S, Mancias P, Kiyama H, Yamanaka K
Mitochondria-associated membrane collapse is a common pathomechanism in SIGMAR1- and SOD1-linked ALS.
EMBO Molecular Medicine 2016, e201606403.

Prese release from Nagoya University

2016/9/27

Prof. K. Yamanaka gave a presentation in the symposium: "Macrophage diversity in life and disease" (organized by Dr. I. Manabe (Chiba Univ.), Dr. Y. Oishi (Medical Research Inst., Tokyo Medical and Dental Univ.)) in the 89th Annual Meeting of the Japanese Biochemical Society.

2016/9/25(Sun)-2016/9/27(Tue) at Sndai International Center

2016/9/10

S. Ohnuma gave a presentation in the 58th Annual Meeting of The Japanese Society for Neurochemistry:

2016/9/8(Thu)-2016/9/10(Sat) at Fukuoka International Congress Center

2016/7/22

Prof. K. Yamanaka and Dr. H. Kawakami (RiRBM, Hiroshima Univ.) organized the sympodium in the 39th Annual Meeting of the Japan Neuroscience Society: "Emerging genes for neurodegenerative diseases: a perspective on pathomechanisms"

We invited Dr. C. Lagier-Tourenne as an invited speaker in the symposium.
S. Watanabe also talked in the symposium. O. Komine and F. Endo gave presentations in the meeting.

2016/7/20(Wed)-22(Fri) at Pacifico Yokohama