Department of Neuroscience and Pathobiology, RIEM, Nagoya University
This laboratory has started since 2013.
Our mission is to uncover the mechanisms of neurodegenerative disorder, motor neuron disease, to develop the viable therapy.
Nov. 17, 2017: Mr. Nishino get a Medical Student Research Award of Nagoya University 2017.
Oct. 21, 2017: We held an extention lecuture of RIEM 2017 entitled as "Efforts to overcome neurodegenerative diseases".
Apr. 2017: New members joined our laboratory.
Nov. 2016: We reported the role of MAM disruption in ALS.
(Watanabe et al. EMBO Molecular Medicine)
Our Recent Activities
Prof. Yamanaka gave presentations in the symposium or meeting listed below:
9/7 60th Anuual Meeting of the Japanese Society for Neurochemistry (Sendai, Japan)
9/19 23rd World Congress of Neurology (WCN) (with 58th Annual Meeting of the Japanese Society of Neurology) (Kyoto, Japan) Mr. Nishino also gave his presentation in theis meeting.
9/28 47th Annual Meeting of the Japanese Society of Neuropsychopharmacology (with 39th Annual Meeting of the Japanese Society of Biological Psychiatry) (Sapporo, Japan)
10/6 29th Annual Meeting of the Japanese Society for Neurochemistry (Sapporo, Japan)
Mr. Nishino won a Medical Student Research Award of Nagoya University 2017.
Our collaborative work with Nagoya City University (Drs. Tsuiji & Hattori) is now in press in Scientific Reports:
We analysed age-dependent changes in TDP-43 transgenic mice, and found the accumulation of abundant poly-ubiquitinated, interneuron-specific protein aggregates in the hippocampus of the aged mice.
Our results indicate that interneuron degeneration, which occurs upon aging, may be related to the impaired memory of TDP-43 transgenic mice.
We held an extention lecuture of RIEM 2017 entitled as "Efforts to overcome neurodegenerative diseases".
A large number of audience came to our lecuture in spite of bad weather, a typhoon.
The lecturers presented interesting and useful information about research/nursing on neurodegenrative diseases such as ALS.
We deeply thank all the lectures for their great presentation, and also thank all the audience.
(1st) Group photo of the lecuturers. Drs. Ikuko Aiba (Higashi-Nagoya National Hospital), Yasumasa Kokubo (Mie Univ.), Hideyuki Okano (Keio Univ.), and Koji Yamanaka (Nagoya Univ.) from the left.
(2nd) A scene in the discussion.
(3rd) A scene in the lecuture by Dr. Yamanaka.
Mr. Kidou & Mr. Inami joined our laboratory. See our members page.
Prof. Yamanaka & Dr. Watanabe gave presentations in the 28th International Symposium on ALS/MND:
2016/12/7(Wed)-9(Fri) at Dublin, Ireland
Prof. Yamanaka gave an ivited talk in the 2nd IMCR Symposium on Endocrine and Metabolism:International Frontiers in Homeostatic Regulation Research:
at Tojo Hall, Gunma University
Dr. Jin leaved for US, and Ms. Higuchi joined us as a technical staff.
Our paper is now in press in EMBO Molecular Medicine:
Mitochondria-associated membrane (MAM) is a contacting site of endoplasmic reticulum and mitochondria, and plays a key role in cellular homeostasis. We identified that disruption of the MAM is tightly involved in the pathology of amyotrophic lateral sclerosis (ALS).
Prof. K. Yamanaka gave a presentation in the symposium: "Macrophage diversity in life and disease" (organized by Dr. I. Manabe (Chiba Univ.), Dr. Y. Oishi (Medical Research Inst., Tokyo Medical and Dental Univ.)) in the 89th Annual Meeting of the Japanese Biochemical Society.
2016/9/25(Sun)-2016/9/27(Tue) at Sndai International Center
S. Ohnuma gave a presentation in the 58th Annual Meeting of The Japanese Society for Neurochemistry:
2016/9/8(Thu)-2016/9/10(Sat) at Fukuoka International Congress Center
Prof. K. Yamanaka and Dr. H. Kawakami (RiRBM, Hiroshima Univ.) organized the sympodium in the 39th Annual Meeting of the Japan Neuroscience Society:
"Emerging genes for neurodegenerative diseases: a perspective on pathomechanisms"
We invited Dr. C. Lagier-Tourenne as an invited speaker in the symposium.
S. Watanabe also talked in the symposium. O. Komine and F. Endo gave presentations in the meeting.
2016/7/20(Wed)-22(Fri) at Pacifico Yokohama
We invited Dr. Clotilde Lagier-Tourenne for the Special Lecture TOKURON 2016: