Department of Neuroscience and Pathobiology, RIEM, Nagoya University
This laboratory has started since 2013.
Our mission is to uncover the mechanisms of neurodegenerative disorder, motor neuron disease, to develop the viable therapy.
Apr. 6, 2018: We reported that innate immune TRIF pathway plays an important role in protecting a microenvironment surrounding motor neurons by eliminating aberrantly activated astrocytes.
(Komine et al. Cell Death Diff)
Apr. 6, 2018: New members joined our laboratory.
Jan. 11, 2018: We reported that CysC ameliorated disease in SOD1-linked ALS model mice.
(Watanabe et al. J Neurochem)
Nov. 17, 2017: Mr. Nishino won a Medical Student Research Award of Nagoya University 2017.
Oct. 21, 2017: We held an extention lecuture of RIEM 2017 entitled as "Efforts to overcome neurodegenerative diseases".
Our Recent Activities
Our paper in Cell Death & Differentiation is now in press:
We revealed for the first time that the innate immune TRIF pathway is involved in eliminating aberrantly activated astrocytes to maintain the microenvironment surrounding motor neurons in ALS mice.
The current study reveals the new roles of innate immunity in ALS pathomechanism and provides a clue to develop a new therapeutic approach for protecting ALS motor neurons.
Our papar is now in press in Journal of Neurochemistry:
We demonstrated that cystatin C, a major component of Bunina bodies in sporadic ALS, extended survival time of SOD1-linked ALS model mice
(+9.6 days; +6.48 % of total), probably via AMP-activated kinase (AMPK) mediated pathways.
Our data suggest that cystatin C may be a novel therapeutic candidate for ALS.
Our members gave presentations in the symposium or meeting listed below:
2017/12/6-9 Conbio2017 (Kobe, Japan) - Speaker: Prof. Yamanaka, & Dr. Watanabe
2017/12/8-10 28th International Symposium on ALS/MND (Boston, USA) - Speaker: Prof. Yamanaka, & Dr. Endo
Prof. Yamanaka gave presentations in the symposium or meeting listed below:
9/7 60th Anuual Meeting of the Japanese Society for Neurochemistry (Sendai, Japan)
9/19 23rd World Congress of Neurology (WCN) (with 58th Annual Meeting of the Japanese Society of Neurology) (Kyoto, Japan) Mr. Nishino also gave his presentation in theis meeting.
9/28 47th Annual Meeting of the Japanese Society of Neuropsychopharmacology (with 39th Annual Meeting of the Japanese Society of Biological Psychiatry) (Sapporo, Japan)
10/6 29th Annual Meeting of the Japanese Society for Neurochemistry (Sapporo, Japan)
Mr. Nishino won a Medical Student Research Award of Nagoya University 2017.
Our collaborative work with Nagoya City University (Drs. Tsuiji & Hattori) is now in press in Scientific Reports:
We analysed age-dependent changes in TDP-43 transgenic mice, and found the accumulation of abundant poly-ubiquitinated, interneuron-specific protein aggregates in the hippocampus of the aged mice.
Our results indicate that interneuron degeneration, which occurs upon aging, may be related to the impaired memory of TDP-43 transgenic mice.
We held an extention lecuture of RIEM 2017 entitled as "Efforts to overcome neurodegenerative diseases".
A large number of audience came to our lecuture in spite of bad weather, a typhoon.
The lecturers presented interesting and useful information about research/nursing on neurodegenrative diseases such as ALS.
We deeply thank all the lectures for their great presentation, and also thank all the audience.
(1st) Group photo of the lecuturers. Drs. Ikuko Aiba (Higashi-Nagoya National Hospital), Yasumasa Kokubo (Mie Univ.), Hideyuki Okano (Keio Univ.), and Koji Yamanaka (Nagoya Univ.) from the left.
(2nd) A scene in the discussion.
(3rd) A scene in the lecuture by Dr. Yamanaka.
Mr. Kidou & Mr. Inami joined our laboratory. See our members page.