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2007年 〜 現在

  • Sakai S, Watanabe S, Komine O, Sobue A, and Yamanaka K: Novel reporters of mitochondria-associated membranes (MAM), MAMtrackers, demonstrate MAM disruption as a common pathological feature in amyotrophic lateral sclerosis. The FASEB Journal e21688, 2021.
  • Sobue A, Komine O, Hara Y, Endo F, Mizoguchi H, Watanabe S, Murayama S, Saito T, Saido T, Sahara N, Higuchi M, Ogi T and Yamanaka K: Microglial gene signature reveals loss of homeostatic microglia associated with neurodegeneration of Alzheimer’s disease. Acta Neuropathologica Communications 9: 1, 2021.
    PDFファイル 名古屋大学によるプレスリリース
  • Saifullah MAB, Komine O, Dong Y, Fukumoto K, Sobue A, Endo F, Saito T, Saido TC, Yamanaka K, Mizoguchi H: Touchscreen-based location discrimination and paired associate learning tasks detect cognitive impairment at an early stage in an App knock-in mouse model of Alzheimer's disease. Molecular Brain 13: 147, 2020.
    PDFファイル 名古屋大学によるプレスリリース
  • Watanabe S, Inami H, Oiwa K, Murata Y, Sakai S, Komine O, Sobue A, Iguchi Y, Katsuno M, Yamanaka K: Aggresome formation and liquid–liquid phase separation independently induce cytoplasmic aggregation of TAR DNA-binding protein 43. Cell Death & Disease 11: 909, 2020.
    PDFファイル 名古屋大学によるプレスリリース
  • Konishi H, Okamoto T, Hara Y, Komine O, Tamada H, Maeda M, Osako F, Kobayashi M, Nishiyama A, Kataoka Y, Takai T, Udagawa N, Jung S, Ozato K, Tamura T, Tsuda M, Yamanaka K, Ogi T, Sato K, Kiyama H: Astrocytic phagocytosis is a compensatory mechanism for microglial dysfunction. EMBO Journal 22: e104464, 2020.
    PDFファイル 名古屋大学によるプレスリリース
  • Amporndanai K, Rogers M, Watanabe S, Yamanaka K, O’Neill P. M., Hasnain S. S.: Novel Selenium-based compounds with therapeutic potential for SOD1-linked Amyotrophic Lateral Sclerosis. EBioMedicine 59: 102980, 2020.
    PDFファイル 名古屋大学によるプレスリリース
  • Sugiyama M, Banno R, Yaginuma H, Taki K, Mizoguchi A, Tsunekawa T, Onoue T, Takagi H, Ito Y, Iwama S, Goto M, Suga H, Komine O, Yamanaka K, Arima H: Hypothalamic glial cells isolated by MACS reveal that microglia and astrocytes induce hypothalamic inflammation via different processes under high-fat diet conditions. Neurochemistry International 136: 104733, 2020.
  • Nakazawa Y, Hara Y, Oka Y, Komine O, van den Heuvel D, Guo C, Daigaku Y, Isono M, He Y, Shimada M, Kato K, Jia N, Hashimoto S, Kotani Y, Miyoshi Y, Tanaka M, Sobue A, Mitsutake N, Suganami T, Masuda A, Ohno K, Nakada S, Mashimo T, Yamanaka K, Luijsterburg MS, Ogi T: Ubiquitination of DNA Damage-Stalled RNAPII Promotes Transcription-Coupled Repair. Cell 180(6): 1228-1244.e24, 2020.
  • Watanabe S, Oiwa K, Murata Y, Komine O, Sobue A, Endo F, Takahashi E and Yamanaka K: ALS-linked TDP-43M337V knock-in mice exhibit splicing deregulation without neurodegeneration. Molecular Brain 13: 8, 2020.
  • Nishino K, Watanabe S, Shijie J, Murata Y, Oiwa K, Komine O, Endo F, Tsuiji H, Abe M, Sakimura K, Mishra A, Yamanaka K: Mice deficient in the C-terminal domain of TAR DNA-binding protein 43 develop age-dependent motor dysfunction associated with impaired Notch1-Akt signaling pathway. Acta Neuropathologica Communications 7(1): 118, 2019.
  • Trias E, Barbeito L, Yamanaka K: Phenotypic heterogeneity of astrocytes in motor neuron disease. Clinical Experimantal Neurology 9(4): 225-234, 2018.
  • Komine O, Yamashita H, Fujimori-Tonou N, Koike M, Jin S, Moriwaki Y, Endo F, Watanabe S, Uematsu S, Akira S, Uchiyama Y, Takahashi R, Misawa H, Yamanaka K: Innate immune adaptor TRIF deficiency accelerates disease progression of ALS mice with accumulation of aberrantly activated astrocytes. Cell Death & Differentiation 25: 2130-2146, 2018.
    PDFファイル 名古屋大学によるプレスリリース
  • Tokuda E, Nomura T, Ohara S, Watanabe S, Yamanaka K, Morisaki Y, Misawa H, Furukawa Y: A copper-deficient form of mutant cu/Zn-superoxide dismutase as an early pathological species in amyotrophic lateral sclerosis. Biochimica et Biophysica Acta 1864(6): 2119-2130, 2018.
  • Watanabe S, Komine O, Fumito E, Wakasugi K, Yamanaka K: Intracerebroventricular administration of Cystatin C ameliorates disease in SOD1-linked amyotrophic lateral sclerosis mice. Journal of Neurochemistry 145(1): 80-89, 2017.
  • Watanabe-Matsumoto S, Moriwaki Y, Okuda T, Ohara S, Yamanaka K, Abe Y, Yasui M, Misawa H: Dissociation of blood-brain barrier disruption and disease manifestation in an aquaporin-4-deficient mouse model of amyotrophic lateral sclerosis. Neuroscience Research 133: 480-57, 2017.
  • Yamanaka K, Komine O: The multi-dimensional roles of astrocytes in ALS. Neuroscience Research 126: 31-38, 2018.
  • Tsuiji H, Inoue I, Takeuchi M, Furuya A, Yamakage Y, Watanabe S, Koike M, Hattori M, Yamanaka K: TDP-43 accelerates age-dependent degeneration of interneurons. Scientific Reports 7: 14972, 2017.
    PDFファイル 名古屋大学によるプレスリリース
  • Yamasaki T, Deki-Arima N, Kaneko A, Miyamura N, Iwatsuki M, Matsuoka M, Fujimori-Tonou N, Okamoto-Uchida Y, Hirayama J, Marth JD, Yamanashi Y, Kawasaki H, Yamanaka K, Penninger JM, Shibata S, Nishina H: Age-dependent motor dysfunction due to neuron-specific disruption of stress-activated protein kinase MKK7. Scientific Reports 7: 7348, 2017.
  • Tokuda E, Anzai I, Nomura T, Toichi K, Watanabe M, Ohara S, Watanabe S, Yamanaka K, Morisaki Y, Misawa H, Furukawa Y: Immunochemical characterization on pathological oligomers of mutant Cu/Zn-superoxide dismutase in amyotrophic lateral sclerosis. Molecular Neurodegeneration 12: 2, 2017.
  • Endo F, Komine O, Yamanaka K: Neuroinflammation in motor neuron disease. Clinical and Experimental Neuroimmunology 7: 126-138, 2016.
  • Watanabe S, Ilieva H, Tamada H, Nomura H, Komine O, Endo F, Jin S, Mancias P, Kiyama H, Yamanaka K: Mitochondria-associated membrane collapse is a common pathomechanism in SIGMAR1- and SOD1-linked ALS. EMBO Molecular Medicine 8(12): 1421-1437, 2016.
     PDFファイル 名古屋大学によるプレスリリース
  • Anzai I, Tokuda E, Mukaiyama A, Akiyama S, Endo F, Yamanaka K, Misawa H, Furukawa Y: A misfolded dimer of Cu/Zn-superoxide dismutase leading to pathological oligomerization in amyotrophic lateral sclerosis. Protein Science 26(3): 484-496, 2016.
  • Amanullah A, Upadhyay A, Chhangani D, Joshi V, Mishra R, Yamanaka K, Mishra A: Proteasomal Dysfunction Induced by Diclofenac Engenders Apoptosis Through Mitochondrial Pathway. Journal of Cellular Biochemistry 118(5): 1014-1027, 2016.
  • Morisaki Y, Niikura M, Watanabe M, Onishi K, Tanabe S, Moriwaki Y, Okuda T, Ohara S, Murayama S, Takao M, Uchida S, Yamanaka K, Misawa H: Selective Expression of Osteopontin in ALS-resistant Motor Neurons is a Critical Determinant of Late Phase Neurodegeneration Mediated by Matrix Metalloproteinase-9. Scientific Reports 6: 27354, 2016.
  • Lasiene J, Komine O, Fujimori-Tonou N, Powers B, Endo F, Watanabe S, Shijie J, Ravits J, Horner P, Misawa H, Yamanaka K: Neuregulin 1 confers neuroprotection in SOD1-linked amyotrophic lateral sclerosis mice via restoration of C-boutons of spinal motor neurons. Acta Neuropathologica Communications 4: 15, 2016
  • Chhangani D, Endo F, Amanullah A, Upadhyay A, Watanabe S, Mishra R, *Yamanaka K, Mishra A: Mahogunin ring finger 1 confers cytoprotection against mutant SOD1 aggresomes and is defective in an ALS mouse model. Neurobiology of Disease 86: 16, 2015.
  • Komine O & Yamanaka K: Neuroinflammation in motor neuron disease. Nagoya Journal of Medical Science 77: 537, 2015.
  • Endo F & Yamanaka K: Astrocytic TGF-β1: detrimental factor in ALS. Oncogene 6: 15728, 2015.
  • Endo F, Komine O, Fujimori-Tonou N, Katsuno M, Jin S, Watanabe S, Sobue G, Dezawa M, Wyss-Coray T, *Yamanaka K: Astrocyte-derived TGF-β1 accelerates disease progression in ALS mice by interfering with the neuroprotective functions of microglia and T cells. Cell Reports 11: 592, 2015.
    PDFファイル 名古屋大学によるプレスリリース
  • Heneka MT, Carson MJ, Khoury JE, Landreth GE, Brosseron F, Feinstein DL, Jacobs AH, Wyss-Coray T, Vitorica J, Ransohoff RM, Herrup K, Frautschy SA, Finsen B, Brown GC, Verkhratsky A, Yamanaka K, Koistinaho J, Latz E, Halle A, Petzold GC, Town T, Morgan D, Shinohara ML, Perry VH, Holmes C, Bazan NG, Brooks DJ, Hunot S, Joseph B, Deigendesch N, Garaschuk O, Boddeke E, Dinarello CA, Breitner JC, Cole GM, Golenbock DT, Kummer MP: Neuroinflammation in Alzheimer’s disease. Lancet Neurology 14: 388, 2015.
  • Watanabe S, Hayakawa T, Wakasugi K, *Yamanaka K: Cystatin C protects neuronal cells against mutant copper-zinc superoxide dismutase-mediated toxicity. Cell Death & Disease, 5: e1497, 2014.
  • Watanabe S, Ageta-Ishihara N, Nagatsu S, Takao K, Komine O, Endo F, Miyakawa T, Misawa H, Takahashi R, Kinoshita M, *Yamanaka K: SIRT1 overexpression ameliorates a mouse model of SOD1-linked amyotrophic lateral sclerosis via HSF1/HSP70i chaperone system. Molecular Brain 7: 62, 2014.
    PDFファイル 名古屋大学によるプレスリリース
  • Austin JA, Wright GS, Watanabe S, Grossmann JG, Antonyuk SV, Yamanaka K, Hasnain SS: Disease causing mutants of TDP-43 nucleic acid binding domains are resistant to aggregation and have increased stability and half-life. Proceedings of the Natural Academy of Sciences, USA 111: 4309-4314, 2014.
  • Nomura T, Watanabe S, Kaneko K, Yamanaka K, Nukina N, Furukawa Y: Intranuclear Aggregation of Mutant FUS/TLS as a Molecular Pathomechanism of Amyotrophic Lateral Sclerosis. The Journal of Biological Chemistry, 289: 1192-1202, 2014.
  • Furukawa Y, Kaneko K, Watanabe S, Yamanaka K, Nukina N: Intracellular seeded aggregation of mutant Cu,Zn-superoxide dismutase associated with amyotrophic lateral sclerosis. FEBS Letters 587: 2500-2505, 2013.
  • Iguchi Y, Katsuno M, Niwa J, Takagi S, Ishigaki S, Ikenaka K, Kawai K, Watanabe H, Yamanaka K, Takahashi R, Misawa H, Sasaki S, Tanaka F, Sobue G: Loss of TDP-43 causes age-dependent progressive motor neuron degeneration. Brain, 136: 1371-1382, 2013.
  • Toichi K, Yamanaka K, Furukawa Y: Disulfide scrambling describes the oligomer formation of superoxide dismutase (SOD1) proteins in the familial form of amyotrophic lateral sclerosis. The Journal of Biological Chemistry, 288: 4970-4980, 2013.
  • Tsuiji H, Iguchi Y, Furuya A, Kataoka A, Hatsuta H, Atsuta N, Tanaka F, Hashizume Y, Akatsu H, Murayama S, Sobue G, *Yamanaka K: Spliceosome integrity is defective in the motor neuron diseases ALS and SMA. EMBO Molecular Medicine, 5: 221-234, 2013.
    理化学研究所によるプレスリリース
  • Watanabe S, Kaneko K, *Yamanaka K: Accelerated disease onset with stabilized familial amyotrophic lateral sclerosis (ALS)-linked TDP-43 mutations. The Journal of Biological Chemistry, 288: 3641-3654, 2012.
    理化学研究所によるプレスリリース
  • Mishra A, Maheshwari M, Chhangani D, Fujimori-Tonou N, Endo, F, Joshi AP, Jana NR, *Yamanaka K. E6-AP association promotes SOD1 aggresomes degradation and suppresses toxicity. Neurobiology of Aging, 34: 1310.e11-23, 2012.
  • Lasiene J, *Yamanaka K: Glial cells in Amyotrophic Lateral Sclerosis. Neurology Research International 2011: 718987, 2011. (review article)
  • Takeuchi H, Mizoguchi H, Doi Y, Jin S, Noda M, Liang J, Li H, Zhou Y, Mori R, Yasuoka S, Li E, Parajuli B, Kawanokuchi J, Sonobe Y, Sato J, Yamanaka K, Sobue G, Mizuno T, Suzumura A: Blockade of Gap Junction Hemichannel Suppresses Disease Progression in Mouse Models of Amyotrophic Lateral Sclerosis and Alzheimer’s Disease. PLoS ONE, 6(6): e21108, 2011.
  • Furukawa Y, Kaneko K, Watanabe S, Yamanaka K, Nukina N: A seeding reaction recapitulates intracellular formation of sarkosyl-insoluble TAR DNA binding protein-43 inclusions. The Journal of Biological Chemistry, 286: 18664-18672, 2011.
  • Israelson A, Arbel N, Da Cruz S, Ilieva H, Yamanaka K, Shoshan-Barmatz V, Clevalend DW: Misfolded Mutant SOD1 Directly Inhibits VDAC1 Conductance in a Mouse Model of Inherited ALS. Neuron, 67: 575-587, 2010.
  • Furukawa Y, Kaneko K, Yamanaka K, Nukina N: Mutation-dependent polymorphism of Cu, Zn-superoxide dismutase aggregates in the familial form of amyotrophic lateral sclerosis. The Journal of Biological Chemistry, 285: 22221-22231, 2010.
  • Lobsiger CS, Boillee S, McAlonis-Downes M, Khan AM, Feltri ML, Yamanaka K, Cleveland DW: Schwann cells expressing dismutase active mutant SOD1 unexpectedly slow disease progression in ALS mice. Proceedings of the Natural Academy of Sciences, USA, 106:4465-4470, 2009.
    理化学研究所によるプレスリリース
  • Cleveland DW, Yamanaka K, Bomont P: Gigaxonin controls vimentin organization through tubulin chaperone-independent pathway. Human Molecular Genetics, 18:1384-1394, 2009.
  • Ilieva H, Yamanaka K, Malkmus S, Kakinohana O, Yaksh T, Marsala M, Cleveland DW: Mutant dynein (Loa) triggers proprioceptive axon loss that extends survival only in the SOD1 ALS model with highest motor neuron death. Proceedings of the Natural Academy of Sciences, USA, 105: 12599-12604, 2008.
  • Yamanaka K, Boillee S, Roberts EA, Garcia ML, McAlonis-Downes M, Mikse OR, Cleveland DW, Goldstein LSB: Mutant SOD1 in cell types other than motor neurons and oligodendrocytes accelerates onset of disease in ALS mice. Proceedings of the Natural Academy of Sciences, USA, 105: 7594-7599, 2008.
  • *Yamanaka K, Chun SJ, Boillee S, Fujimori-Tonou N, Yamashita H, Gutmann DH, Takahashi R, Misawa H, Cleveland DW: Astrocytes as determinants of disease progression in inherited amyotrophic lateral sclerosis. Nature Neuroscience, 11: 251-253, 2008.
    Highlighted as a “Fast Breaking Paper” by Thomson Reuter (2009.4)
    理化学研究所によるプレスリリース
  • Furukawa Y, Kaneko K, Yamanaka K, O’Halloran, TV, Nukina N: Complete loss of post-translational modifications triggers fibrillar aggregation of SOD1 in familial form of ALS. The Journal of Biological Chemistry 283: 24167-24176, 2008.
  • Yamashita H, Kawamata J, Okawa K, Kanki R, Nakamizo T, Hatayama T, Yamanaka K, Takahashi R, Shimohama S: Heat-shock protein 105 interacts with and suppresses aggregation of mutant Cu/Zn superoxide dismutase; clues to a possible strategy for treating ALS. Journal of Neurochemistry, 102: 1497-1505, 2007.

2006年以前 (抜粋)

  • Boillee S, Yamanaka K, Lobsiger CS, Copeland NG, Jenkins NA, Kassiotis G, Kollias G, Cleveland DW: Onset and Progression in Inherited ALS determined by Motor Neurons and Microglia. Science, 312: 1389-1392, 2006. # Co-first authors
  • Miller TM, Kim SH, Yamanaka K, Hester M, Umapathi P, Arnson H, Rizo L, Mendell JR, Gage FH, Cleveland DW, Kaspar BK: Gene transfer demonstrates that muscle is not a primary target for non-cell autonomous toxicity in familial amyotrophic lateral sclerosis. Proceedings of the Natural Academy of Sciences, USA, 103: 19546-19551, 2006.
  • Smith RA, Miller TM, Yamanaka K, Monia BP, Condon TP, Hung G, Lobsiger CS, Ward CM, McAlonis-Downes M, Wei H, Wancewicz EV, Bennett CF, Cleveland DW: Antisense Oligonucleotides as a Therapy for Neurodegenerative diseases. Journal of Clinical Investments, 116: 2290-2296, 2006.
  • Yamanaka K*, Miller TM, McAlonis-Downes M, Chun SJ, Cleveland DW: Progressive axonal degeneration and slowness in ALS2-deficient mice. Annals of Neurology, 60: 95-104, 2006.
  • Eymard-Pierre E, Yamanaka K, Haeussler M, Kress W, Gauthier-Barichard F, Combes P, Cleveland DW, Boespflug-Tanguy O: Novel Missense Mutation in ALS2 gene results in Infantile Ascending Hereditary Spastic Paralysis. Annals of Neurology, 59: 976-980, 2006.
  • Miller TM, Kaspar BK, Kops GJ, Yamanaka K, Christian LJ, Gage FH, Cleveland DW: Virus-delivered siRNA preserves strength in ALS mice. Annals of Neurology, 57: 773-776, 2005.
  • Yamanaka K, Vande Velde C, Eymard-Pierre E, Bertini E, Boespflug-Tanguy O, Cleveland DW: Unstable mutants in the peripheral endosomal membrane component ALS2 cause early onset motor neuron disease. Proceedings of the Natural Academy of Sciences, USA, 100: 16041-16046, 2003.
  • Yamanaka K, Ishikawa H, Megumi Y, Tokunaga F, Kanie M, Rouault TA, Morishima I, Minato N, Ishimori K, Iwai K: Identification of the ubiquitin-protein ligase that recognizes oxidized IRP2. Nature Cell Biology 5: 336-340, 2003.
  • Bertini E, Eymard-Pierre E, Boespflug-Tanguy O, Cleveland DW, Yamanaka K: ALS2-Related Disorders. In: GeneReviews at GeneTests: Medical Genetics Information Resource. Copyright, University of Washington, Seattle. 2005. Revised in 2011. Available at http://www.genetests.org. (peer-reviewed online review)
  • Yamanaka K, Cleveland DW: Determinants of rapid disease progression in ALS. Neurology, 65: 1859-1860, 2005.

和文総説・著書など

  • 渡邊 征爾, 山中 宏二 : 筋萎縮性側索硬化症におけるMAMの破綻 実験医学 37(12): 138-144, 2019.
  • 渡邊 征爾, 山中 宏二 : 第7回 筋萎縮性側索硬化症(ALS) 和光純薬時報 86(4): 18-20, 2018.
  • Hitomi Tsuiji, Koji Yamanaka : Animal Models for Neurodegenerative Disorders. In:Verma A, Singh A, editors. Animal Biotechnology: Models in Discovery and Translation, Elsevier, pp39-56, 2014.
  • 遠藤史人, 山中宏二 : 筋萎縮性側索硬化症におけるグリア病態・神経炎症 医学のあゆみ 248(12): 901-906, 2014.
  • 山中宏二 : 炎症と神経変性.(企画) 医学のあゆみ 248(12): 879-911, 2014.
  • 山下博史,山中宏二 : ALS病態におけるグリアの役割. 脳21 15(1): 28-33, 2012.
  • 山中宏二 : ALS におけるグリア関連病態. 臨床神経学 51: 1192-1194, 2011.
  • 山下博史, 山中宏二 : ALS-SOD1の発症機序. Clinical Neuroscience 29: 1044-1045, 2011.
  • 山中宏二 : 神経変性疾患における細胞死研究のパラダイムシフト. 実験医学 別冊 羊土社, 2010, p1188-1194.
  • 山中宏二, 遠藤史人: ALSの病態—非細胞自律性の神経細胞死. 医学のあゆみ 235: 241-245, 2010.
  • 山中宏二 : ALSの今後の研究方向と可能性は. MB Medical Rehabilitation 113: 13-18, 2009.
  • 山中宏二 : 筋萎縮性側索硬化症とグリア細胞. Medical Science Digest, 35: 262-263, 2009.
  • 山中宏二, 渡辺祥司 : 筋萎縮性側索硬化症: 非細胞自律性の神経細胞死. 神経内科 68: 140-146, 2008.
  • 山中宏二 : 筋萎縮性側索硬化症の動物モデル. 臨床神経学 47: 934-937,2007.
  • 山中宏二, 山下博史 : ALSとミクログリア―非細胞自律性の神経細胞死. Brain and Nerve 59:1163-1170, 2007.
  • 山中宏二 : ALS研究のトピックスー非細胞自律性の神経細胞死 実験医学増刊: 脳神経疾患の分子病態と治療への展開 羊土社, 2007, p109-114.
  • 山中宏二 : ALSの発症と進行は運動ニューロンとミクログリアが規定する. 実験医学 24: 2509-2512, 2006.