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研究業績

英文論文・著書

  • Horigane S, Ozawa Y, Yamada H, Takemoto-Kimura S. Calcium signalling: a key regulator of neuronal migration. J Biochem 1;165(5):401-409. (2019)
  • Inoue M, Takeuchi A, Manita S, Horigane S, Sakamoto M, Kawakami R, Yamaguchi K, Otomo K, Yokoyama H, Kim R, Yokoyama T, Takemoto-Kimura S, Abe M, Okamura M, Kondo Y, Quirin S, Ramakrishnan C, Imamura T, Sakimura K, Nemoto T, Kano M, Fujii H, Deisseroth K, Kitamura K, Bito H. Rational Engineering of XCaMPs, a Multicolor GECI Suite for In Vivo Imaging of Complex Brain Circuit Dynamics. Cell 16;177(5):1346-1360. (2019)
  • Kamijo S, Ishii Y, Horigane S, Suzuki K, Ohkura M, Nakai J, Fujii H, Takemoto-Kimura S, *Bito H. A Critical Neurodevelopmental Role for L-Type Voltage-Gated Calcium Channels in Neurite Extension and Radial Migration. Journal of Neuroscience 38(24):5551-5566 (2018)
  • Nishiguchi KM, Fujita K, Tokashiki N, Komamura H, Takemoto-Kimura S, Okuno H, Bito H, *Nakazawa T. Retained Plasticity and Substantial Recovery of Rod-Mediated Visual Acuity at the Visual Cortex in Blind Adult Mice with Retinal Dystrophy. Molecular Therapy 26(10):2397-2406.(2018)
  • Takemoto-Kimura S, Horigane S. Exploring the function of calcium-dependent phosphorylation in neuronal morphogenesis and circuit formation. Jpn. J. Neuropsychopharmaol 37:163-167. (2017)
  • Takemoto-Kimura S, Horigane S, Kamijo S,Inoue M,Sakamoto M,Fujii H,Bito H*. Calmodulin kinases: essential regulators in health and disease. J Neurochem 141:808-818. doi: 10.1111/jnc.14020. (2017)
  • Takemoto-Kimura S, Horigane S. Exploring the function of calcium-dependent phosphorylation in neuronal morphogenesis and circuit formation. Jpn. J. Neuropsychopharmaol 37:163-167. (2017)
  • Horigane S, Ageta-Ishihara N, Kamijo S, Fujii H, Okamura M, Kinoshita M, Takemoto-Kimura S*, Bito H*. Facilitation of axon outgrowth via a Wnt5a-CaMKK-CaMKIalpha pathway during neuronal polarization. Molecular Brain 16;9(1):8. doi:10.1186/s13041-016-0189-3 (2016) (*co-corresponding authors)
  • Inoue M, Takeuchi A, Horigane S, Ohkura M, Gengyo-Ando K, Fujii H, Kamijo S, Takemoto-Kimura S, Kano M, Nakai J, Kitamura K, BitoH: Rational design of a high-affinity, fast, red calcium indicator R-CaMP2. Nat Methods 12(1): 64-70 (2015)
  • Nonaka M, Kim R, Sharry S, Matsushima A, Takemoto-Kimura S, Bito H: Towards a better understanding of cognitive behaviors regulated by gene expression downstream of activity-dependent transcription factors. Neurobiol Learn Mem 115: 21-9 (2014)
  • Nonaka M, Kim R, Fukushima H, Sasaki K, Suzuki K, Okamura M, Ishii Y, Kawashima T, Kamijo S, Takemoto-Kimura S, Okuno H, Kida S, Bito H.: Region-Specific Activation of CRTC1-CREB Signaling Mediates Long-Term Fear Memory. Neuron 84(1): 92-106 (2014)
  • Kawashima T, Kitamura K, Suzuki K, Nonaka M, Kamijo S, Takemoto-Kimura S, Kano M, Okuno H, Ohki K, Bito H. Functional labeling of neurons and their projections using the synthetic activity-dependent promoter E-SARE. Nat Methods 10, 889-895 (2013)
  • Fujii H, Inoue M, Okuno H, Sano Y, Takemoto-Kimura S, Kitamura K, Kano M, Bito H. Nonlinear decoding and asymmetric representation of neuronal input information by CaMKIIα and calcineurin. Cell Rep 3, 978-987 (2013)
  • Okuno H, Akashi K, Ishii Y, Yagishita-Kyo N, Suzuki K, Nonaka M, Kawashima T, Fujii H, Takemoto-Kimura S, Abe M, Natsume R, Chowdhury S, Sakimura K, Worley PF and Bito H. Inverse Synaptic Tagging of Inactive Synapses via Dynamic Interaction of Arc/Arg3.1 with CaMKIIbeta. Cell 149, 886-898 (2012)
  • Ageta-Ishihara N, Takemoto-Kimura S, Nonaka M, Adachi-Morishima A, Suzuki K, Kamijo S, Fujii H, Mano T, Blaeser F, Chatila TA, Mizuno H, Hirano T, Tagawa Y, Okuno H and Bito H. Control of cortical axon elongation by a GABA-driven Ca2+/calmodulin-dependent protein kinase cascade. J Neurosci 29, 13720-13729 (2009)
  • Kawashima T, Okuno H, Nonaka M, Adachi-Morishima A, Kyo N, Okamura M, Takemoto-Kimura S, Worley PF and Bito H. Synaptic activity-responsive element in the Arc/Arg3.1 promoter essential for synapse-to-nucleus signaling in activated neurons. Proc Natl Acad Sci USA 106, 316-321 (2009)
  • Bito H, Takemoto-Kimura S, Okuno H. Activity-dependent gene regulation: How do synapses talk to the nucleus and fine-tune neuronal outputs? in “Molecular Pain“. (M. Zhuo ed., Springer, New York), 207-217 (2008)
  • Takemoto-Kimura S, Ageta-Ishihara N, Nonaka M, Adachi-Morishima A, Mano T, Okamura M, Fujii H, Fuse T, Hoshino M, Suzuki S, Kojima M, Mishina M, Okuno H and Bito H. Regulation of dendritogenesis via a lipid-raft-associated Ca2+/calmodulin-dependent protein kinase CLICK-III/CaMKIgamma. Neuron 54, 755-770 (2007)
  • Fuse T, Ohmae S, Takemoto-Kimura S, Bito H. DCLK1.
    AfCS/Nature Molecule Pages, doi:10.1038/mp.a003011.01 (2007)
  • Sato K, Suematsu A, Nakashima T, Takemoto-Kimura S, Aoki K, Morishita Y, Asahara H, Ohya K, Yamaguchi A, Takai T, Kodama T, Chatila TA, Bito H and Takayanagi H. Regulation of osteoclast differentiation and function by the CaMK-CREB pathway. Nat Methods 12, 1410-1416 (2006)
  • Ohmae S, Takemoto-Kimura S, Okamura M, Adachi-Morishima A., Nonaka M, Fuse T, Kida S, Tanji M, Furuyashiki T, Arakawa Y, Narumiya S, Okuno H and Bito H. Molecular identification and characterization of a family of kinases with homology to Ca2+/calmodulin-dependent protein kinases I/IV. J Biol Chem 281, 20427-20439 (2006)
  • Nonaka M, Doi T, Fujiyoshi Y, Takemoto-Kimura S and Bito H. Essential contribution of the ligand-binding beta B/beta C loop of PDZ1 and PDZ2 in the regulation of postsynaptic clustering, scaffolding, and localization of postsynaptic density-95. J Neurosci 26, 763-774 (2006)
  • Takemoto-Kimura S, Terai H, Takamoto M, Ohmae S, Kikumura S, Segi E, Arakawa Y, Furuyashiki T, Narumiya S and Bito H. Molecular cloning and characterization of CLICK-III/CaMKIgamma, a novel membrane-anchored neuronal Ca2+/calmodulin-dependent protein kinase (CaMK). J Biol Chem 278, 18597-18605 (2003)
  • Arakawa Y, Bito H, Furuyashiki T, Tsuji T, Takemoto-Kimura S, Kimura K, Nozaki K, Hashimoto N and Narumiya S. Control of axon elongation via an SDF-1alpha/Rho/mDia pathway in cultured cerebellar granule neurons. J Cell Biol 161, 381-391 (2003)
  • Bito H and Takemoto-Kimura S. Ca2+/CREB/CBP-dependent gene regulation: a shared mechanism critical in long-term synaptic plasticity and neuronal survival.
    Cell Calcium 34, 425-430 (2003)
  • Furuyashiki T, Arakawa Y, Takemoto-Kimura S, Bito H and Narumiya S. Multiple spatiotemporal modes of actin reorganization by NMDA receptors and voltage-gated Ca2+ channels. Proc Natl Acad Sci USA 99, 14458-14463 (2002)

日本語総説・著書

  • 堀金慎一郎竹本さやか
    細胞内 Ca2+シグナリングを介した発生期神経細胞移動の制御。日本生物学的精神医学会誌 30(1) (2019)
  • 竹本-木村さやか
    CaMKK-CaMKI経路による神経突起伸展の制御と大脳皮質構築。神経化学 51(3), 65-70 (2012)
  • 竹本-木村さやか、上田(石原)奈津実、布施俊光、上條諭志、尾藤晴彦
    神経疾患と細胞骨格。分子細胞治療 8, 243-248 (2009)
  • 井上昌俊、川島尚之、野中美応、竹本-木村さやか、奥野浩行、尾藤晴彦
    シナプス長期可塑性の分子基盤。Cognition and Dementia 8, 177-182 (2009)
  • Bito H, Nonaka M, Fuse T, Fujii H, Takemoto-Kimura S and Okuno H. Molecular mechanisms underlying the regulation of synapse function and the molecular architecture of the postsynaptic density. Tanpakushitsu Kakusan Koso 53, 418-423 (2008)
  • Okuno H, Takemoto-Kimura S, Ohmae S, Okamura M, Ishihara N and Bito H. Synaptic activity-dependent regulation of neuronal gene expression.
    Tanpakushitsu Kakusan Koso 49, 411-418 (2004)
  • 尾藤晴彦、竹本-木村さやか、大前彰吾、古屋敷智之、奥野浩行.
    Ca2+とCaMキナーゼによるシナプス可塑性制御 (実験医学増刊号no.102「脳神経研究2004」pp.119-124) 実験医学 21, 2393-2398 (2003)
  • 古屋敷智之、荒川芳輝、竹本-木村さやか、尾藤晴彦、成宮周.
    神経活動によるアクチン細胞骨格制御とその多様性.
    実験医学別冊「バイオイメージングでここまで解る」 32-36 (2002)
  • 尾藤晴彦、古屋敷智之、竹本-木村さやか、荒川芳輝、成宮周.
    マウス海馬錐体細胞初代培養法.実験医学 20, 2247-2252 (2002)
  • 名古屋大学 環境医学研究所
  • 名古屋大学大学院医学系研究科
  • 名古屋大学