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研究業績

原著論文

    2023
  • Ageta-Ishihara N#, Takemoto-Kimura S#, Kondo Y, Okamura M, Bito H. (#equal contribution)
    Lipidation states orchestrate CLICK-III/CaMKIγ's stepwise association with Golgi and rafts-enriched membranes and specify its functional coupling to STEF-Rac1-dependent neurite extension.
    Front. Cell. Neurosci. 2023 Aug 3;17:1204302.
  • Hamada S#, Mikami K#, Ueda S#, Nagase M#, Nagashima T, Yamamoto M, Bito H, Takemoto-Kimura S, Ohtsuka T, Watabe AM. (#equal contribution)
    Experience-dependent changes in affective valence of taste in male mice.
    Mol. Brain 2023 Mar 11;16(1):28.

  • 2022
  • Fujii H, Kidokoro H, Kondo Y, Kawaguchi M, Horigane S, Natsume J, Takemoto-Kimura S, Bito H.
    Förster resonance energy transfer-based kinase mutation phenotyping reveals an aberrant facilitation of Ca2+/calmodulin-dependent CaMKIIα activity in de novo mutations related to intellectual disability.
    Front. Mol. Neurosci. 2022 Sep 1;15:970031.
  • Wang C#, Horigane S#, Wakamori M#, Ueda S, Kawabata T, Fujii H, Kushima I, Kimura H, Ishizuka K, Nakamura Y, Iwayama Y, Ikeda M, Iwata N, Okada T, Aleksic B, Mori D, Yoshida T, Bito H, Yoshikawa T, Takemoto-Kimura S, Ozaki N.
    (#equal contribution, co-corresponding authors)
    Identification of ultra-rare disruptive variants in voltage-gated calcium channel-encoding genes in Japanese samples of schizophrenia and autism spectrum disorder.
    Transl. Psychiatry 2022 Feb 26;12(1):84.
  • Sakamoto M, Inoue M, Takeuchi A, Kobari S, Yokoyama T, Horigane S, Takemoto-Kimura S, Abe M, Sakimura K, Kano M, Kitamura K, Fujii H, Bito H.
    A Flp-dependent G-CaMP9a transgenic mouse for neuronal imaging in vivo.
    Cell Rep. Methods 2022 Feb 14;2(2):100168.

  • 2021
  • Ueda S, Hosokawa M, Arikawa K, Takahashi K, Fujiwara M, Kakita M, Fukada T, Koyama H, Horigane S, Itoi K, Kakeyama M, Matsunaga H, Takeyama H, Bito H, Takemoto-Kimura S.
    Distinctive Regulation of Emotional Behaviors and Fear-Related Gene Expression Responses in Two Extended Amygdala Subnuclei With Similar Molecular Profiles.
    Front. Mol. Neurosci. 2021 Sep 3;14:741895.
  • Matsubara T, Yanagida T, Kawaguchi N, Nakano T, Yoshimoto J, Sezaki M, Takizawa H, Tsunoda SP, Horigane S, Ueda S, Takemoto-Kimura S, Kandori H, Yamanaka A, Yamashita T.
    Remote control of neural function by X-ray-induced scintillation.
    Nat. Commun. 2021 Jul 22;12(1):4478.

  • 2020
  • Horigane S#, Ozawa Y#, Zhang J#, Todoroki H, Pan M, Haijima A, Yanagawa Y, Ueda S, Nakamura S, Kakeyama M, Takemoto-Kimura S.
    (#equal contribution, co-corresponding authors)
    A mouse model of Timothy syndrome exhibits altered social competitive dominance and inhibitory neuron development.
    FEBS Open Bio 2020 Aug;10(8):1436-1446.
  • Horigane S, Hamada S, Kamijo S, Yamada H, Yamasaki M, Watanabe M, Bito H, Ohtsuka T, Takemoto-Kimura S.
    Development of an L-type Ca2+ channel-dependent Ca2+ transient during the radial migration of cortical excitatory neurons.
    Neurosci. Res. 2020 Jun 26;169:17-26.

  • 2019
  • Inoue M, Takeuchi A, Manita S, Horigane S, Sakamoto M, Kawakami R, Yamaguchi K, Otomo K, Yokoyama H, Kim R, Yokoyama T, Takemoto-Kimura S, Abe M, Okamura M, Kondo Y, Quirin S, Ramakrishnan C, Imamura T, Sakimura K, Nemoto T, Kano M, Fujii H, Deisseroth K, Kitamura K, Bito H.
    Rational Engineering of XCaMPs, a Multicolor GECI Suite for In Vivo Imaging of Complex Brain Circuit Dynamics.
    Cell 2019 May 16;177(5):1346-1360.

  • 2018
  • Nishiguchi KM, Fujita K, Tokashiki N, Komamura H, Takemoto-Kimura S, Okuno H, Bito H, Nakazawa T.
    Retained Plasticity and Substantial Recovery of Rod-Mediated Visual Acuity at the Visual Cortex in Blind Adult Mice with Retinal Dystrophy.
    Mol. Ther. 2018 Oct 3;26(10):2397-2406.
  • Kamijo S, Ishii Y, Horigane S, Suzuki K, Ohkura M, Nakai J, Fujii H, Takemoto-Kimura S, Bito H.
    A Critical Neurodevelopmental Role for L-Type Voltage-Gated Calcium Channels in Neurite Extension and Radial Migration.
    J. Neurosci. 2018 Jun 13;38(24):5551-5566.

  • 2016
  • Horigane S#, Ageta-Ishihara N#, Kamijo S, Fujii H, Okamura M, Kinoshita M, Takemoto-Kimura S, Bito H.
    (#equal contribution, co-corresponding authors)
    Facilitation of axon outgrowth via a Wnt5a-CaMKK-CaMKIalpha pathway during neuronal polarization.
    Mol. Brain 2016 Jan 16;9:8.

  • 2015
  • Inoue M, Takeuchi A, Horigane S, Ohkura M, Gengyo-Ando K, Fujii H, Kamijo S, Takemoto-Kimura S, Kano M, Nakai J, Kitamura K, Bito H.
    Rational design of a high-affinity, fast, red calcium indicator R-CaMP2.
    Nat. Methods 2015 Jan;12(1):64-70.

  • 2014
  • Nonaka M, Kim R, Fukushima H, Sasaki K, Suzuki K, Okamura M, Ishii Y, Kawashima T, Kamijo S, Takemoto-Kimura S, Okuno H, Kida S, Bito H.
    Region-Specific Activation of CRTC1-CREB Signaling Mediates Long-Term Fear Memory.
    Neuron 2014 Oct 1;84(1):92-106.

  • 2013
  • Kawashima T, Kitamura K, Suzuki K, Nonaka M, Kamijo S, Takemoto-Kimura S, Kano M, Okuno H, Ohki K, Bito H.
    Functional labeling of neurons and their projections using the synthetic activity-dependent promoter E-SARE.
    Nat. Methods 2013 Sep;10(9):889-95.
  • Fujii H, Inoue M, Okuno H, Sano Y, Takemoto-Kimura S, Kitamura K, Kano M, Bito H.
    Nonlinear decoding and asymmetric representation of neuronal input information by CaMKIIα and calcineurin.
    Cell Rep. 2013 Apr 25;3(4):978-87.

  • 2012
  • Okuno H, Akashi K, Ishii Y, Yagishita-Kyo N, Suzuki K, Nonaka M, Kawashima T, Fujii H, Takemoto-Kimura S, Abe M, Natsume R, Chowdhury S, Sakimura K, Worley PF, Bito H.
    Inverse Synaptic Tagging of Inactive Synapses via Dynamic Interaction of Arc/Arg3.1 with CaMKIIbeta.
    Cell 2012 May 11;149(4):886-98.

  • 2009
  • Ageta-Ishihara N, Takemoto-Kimura S, Nonaka M, Adachi-Morishima A, Suzuki K, Kamijo S, Fujii H, Mano T, Blaeser F, Chatila TA, Mizuno H, Hirano T, Tagawa Y, Okuno H, Bito H.
    Control of cortical axon elongation by a GABA-driven Ca2+/calmodulin-dependent protein kinase cascade.
    J. Neurosci. 2009 Oct 28;29(43):13720-9.
  • Kawashima T, Okuno H, Nonaka M, Adachi-Morishima A, Kyo N, Okamura M, Takemoto-Kimura S, Worley PF, Bito H.
    Synaptic activity-responsive element in the Arc/Arg3.1 promoter essential for synapse-to-nucleus signaling in activated neurons.
     Proc. Natl. Acad. Sci. USA 2009 Jan 6;106(1):316-21.

  • 2007
  • Takemoto-Kimura S#, Ageta-Ishihara N#, Nonaka M, Adachi-Morishima A, Mano T, Okamura M, Fujii H, Fuse T, Hoshino M, Suzuki S, Kojima M, Mishina M, Okuno H, Bito H.  (#equal contribution)
    Regulation of dendritogenesis via a lipid-raft-associated Ca2+/calmodulin-dependent protein kinase CLICK-III/CaMKIgamma.
    Neuron 2007 Jun 7;54(5):755-70.

  • 2006
  • Sato K, Suematsu A, Nakashima T, Takemoto-Kimura S, Aoki K, Morishita Y, Asahara H, Ohya K, Yamaguchi A, Takai T, Kodama T, Chatila TA, Bito H, Takayanagi H.
    Regulation of osteoclast differentiation and function by the CaMK-CREB pathway.
    Nat. Methods 2006 Dec;12(12):1410-6
  • Ohmae S#, Takemoto-Kimura S#, Okamura M#, Adachi-Morishima A#, Nonaka M, Fuse T, Kida S, Tanji M, Furuyashiki T, Arakawa Y, Narumiya S, Okuno H, Bito H.  (#equal contribution)
    Molecular identification and characterization of a family of kinases with homology to Ca2+/calmodulin-dependent protein kinases I/IV.
    J. Biol. Chem. 2006 Jul 21;281(29):20427-39.
  • Nonaka M, Doi T, Fujiyoshi Y, Takemoto-Kimura S, Bito H.
    Essential contribution of the ligand-binding beta B/beta C loop of PDZ1 and PDZ2 in the regulation of postsynaptic clustering, scaffolding, and localization of postsynaptic density-95.
    J. Neurosci. 2006 Jan 18;26(3):763-74.

  • 2003
  • Arakawa Y, Bito H, Furuyashiki T, Tsuji T, Takemoto-Kimura S, Kimura K, Nozaki K, Hashimoto N, Narumiya S.
    Control of axon elongation via an SDF-1alpha/Rho/mDia pathway in cultured cerebellar granule neurons.
    J. Cell Biol. 2003 Apr 28;161(2):381-91.
  • Takemoto-Kimura S, Terai H, Takamoto M, Ohmae S, Kikumura S, Segi E, Arakawa Y, Furuyashiki T, Narumiya S, Bito H.
    Molecular cloning and characterization of CLICK-III/CaMKIgamma, a novel membrane-anchored neuronal Ca2+/calmodulin-dependent protein kinase (CaMK).
    J. Biol. Chem. 2003 May 16;278(20):18597-605.

  • 2002
  • Furuyashiki T, Arakawa Y, Takemoto-Kimura S, Bito H, Narumiya S.
    Multiple spatiotemporal modes of actin reorganization by NMDA receptors and voltage-gated Ca2+ channels.
    Proc. Natl. Acad. Sci. USA 2002 Oct 29;99(22):14458-63.

英文総説・著書

  • Horigane S, Ozawa Y, Yamada H, Takemoto-Kimura S.
    Calcium signalling: a key regulator of neuronal migration.
    J. Biochem. 2019 May 1;165(5):401-409.
  • Takemoto-Kimura S, Horigane S, Kamijo S, Inoue M, Sakamoto M, Fujii H, Bito H.
    Calmodulin kinases: essential regulators in health and disease.
    J. Neurochem. 2017 Jun;141(6):808-818.
  • Nonaka M, Kim R, Sharry S, Matsushima A, Takemoto-Kimura S, Bito H.
    Towards a better understanding of cognitive behaviors regulated by gene expression downstream of activity-dependent transcription factors.
    Neurobiol. Learn. Mem. 2014 Nov;115:21-9.
  • Bito H, Takemoto-Kimura S, Okuno H.
    Activity-dependent gene regulation: How do synapses talk to the nucleus and fine-tune neuronal outputs?
    in “Molecular Pain“ (M. Zhuo ed., Springer, New York) 207-217 (2008)
  • Fuse T, Ohmae S, Takemoto-Kimura S, Bito H.
    DCLK1.
    AfCS/Nature Molecule Pages (2007)
  • Bito H, Takemoto-Kimura S.
    Ca2+/CREB/CBP-dependent gene regulation: a shared mechanism critical in long-term synaptic plasticity and neuronal survival.
    Cell Calcium 2003 Oct-Nov;34(4-5):425-30.

和文総説・著書

  • 堀金慎一郎竹本さやか
    細胞内 Ca2+シグナリングを介した発生期神経細胞移動の制御
    日本生物学的精神医学会誌 30(1) (2019)
  • Takemoto-Kimura S, Horigane S.
    Exploring the function of calcium-dependent phosphorylation in neuronal morphogenesis and circuit formation.
    Jpn. J. Neuropsychopharmaol. 37:163-167 (2017)
  • 竹本-木村さやか
    CaMKK-CaMKI経路による神経突起伸展の制御と大脳皮質構築
    神経化学 51(3), 65-70 (2012)
  • 竹本-木村さやか、上田(石原)奈津実、布施俊光、上條諭志、尾藤晴彦
    神経疾患と細胞骨格
    分子細胞治療 8, 243-248 (2009)
  • 井上昌俊、川島尚之、野中美応、竹本-木村さやか、奥野浩行、尾藤晴彦
    シナプス長期可塑性の分子基盤
    Cognition and Dementia 8, 177-182 (2009)
  • Bito H, Nonaka M, Fuse T, Fujii H, Takemoto-Kimura S, Okuno H.
    Molecular mechanisms underlying the regulation of synapse function and the molecular architecture of the postsynaptic density.
    Tanpakushitsu Kakusan Koso 53, 418-423 (2008)
  • Okuno H, Takemoto-Kimura S, Ohmae S, Okamura M, Ishihara N, Bito H.
    Synaptic activity-dependent regulation of neuronal gene expression.
    Tanpakushitsu Kakusan Koso 49, 411-418 (2004)
  • 尾藤晴彦、竹本-木村さやか、大前彰吾、古屋敷智之、奥野浩行
    Ca2+とCaMキナーゼによるシナプス可塑性制御 (実験医学増刊号「脳神経研究2004」)
    実験医学 21(17), 2393-2398 (2003)
  • 古屋敷智之、荒川芳輝、竹本-木村さやか、尾藤晴彦、成宮周
    神経活動によるアクチン細胞骨格制御とその多様性(実験医学別冊「バイオイメージングでここまで理解る」)
    実験医学別冊 32-36 (2002)
  • 尾藤晴彦、古屋敷智之、竹本-木村さやか、荒川芳輝、成宮周
    マウス海馬錐体細胞初代培養法 (クローズアップ実験法)
    実験医学 20(15), 2247-2252 (2002)
  • 名古屋大学 環境医学研究所
  • 名古屋大学大学院医学系研究科
  • 名古屋大学