Research Institute of Environmental Medicine Nagoya University

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Research Center for Next-Generation Drug Development

Staff

Assistant Professor
Hiroyuki Mizoguchi
Assistant Professor
Yasuhiko Kanou

Research Projects

(Under construction)

Recent publications (2010.4-2014.3)

  1. Ibi D, Nagai T, Nakajima A, Mizoguchi H, Kawase T,Tsuboi D, Kano S, Sato Y, Hayakawa M, Lange UC, Adams DJ, Rueani MA, Satoh T, Sawa A, Kaibuchi K, Nabeshima T, Yamada K: Astroglial IFITM3 mediates neuronal impairments following neonatal immune challenge in mice. Glia 61(5):679-693, 2013.
  2. Ohmichi M, Ohmichi Y, Ohnishi H, Yoshimoto T, Morimoto A, Li Y, Sakurai H, Nanano T, Sato J: Activated spinal astrocytes are involved in the maintenance of chronic widespread mechanical hyperalgesia after cast immobilization. Molecular Pain, in press, 2014.
  3. Mizoguchi H, Yamada K: Roles of matrix metalloproteinases and their targets in epileptogenesis and seizures. Clinical Psychopharmacology and Neuroscience 11(2): 45–52, 2013.
  4. Takuma K, Mizoguchi H, Funatsu Y, Hoshina Y, Himeno Y, Fukuzaki E, Kitahara Y, Arai S, Ibi D, Kamei H, Matsuda T, Koike K, Inoue M, Nagai T, Yamada K: Combination of chronic stress and ovariectomy causes conditioned fear memory deficites and hippocampal cholinergic neuronal loss in mice. Neuroscience 207: 261-73, 2012.
  5. Nakamoto K, Kawasaki S, Kobori T, Fujita-Hamabe W, Mizoguchi H, Yamada K, Nabeshima T, Tokuyama S: Involvement of matrix metalloproteinases-9 in the development of morphine tolerance. European Journal of Pharmacology 683(1-3): 86-92, 2012.
  6. Takuma K, Mizoguchi H, Funatsu Y, Kitahara Y, Ibi D, Kamei H, Matsuda T, Koike K, Inoue M, Nagai T, Yamada K: Placental extract improves hippocampal neuronal loss and fear memory impairment resulting from chronic restraint stress in ovariectomized mice. Journal of Pharmacological Sciences 120: 89-97, 2012.
  7. Arai YCP, Morimoto A, Sakurai H, Ohmichi Y, Aono S, Nishihara M, Sato J, Ushida T, Inoue S, Kurisuno M, Kobayashi Y: The effect of celiac plexus block on heart rate variability. Journal of Anesthesia 27(1): 62-65, 2013.
  8. Arai YCP, Nishihara M, Kobayashi K, Kanazawa T, Hayashi N, Tohyama Y, Nishida K, Arakawa M, Suzuki C, Kinoshita A, Kondo M, Matsubara S, Yokoe N, Hayashi R, Ohta A, Sato J, Ushida T: Neurolytic celiac plexus block reduces occurrence and duration of terminal delirium in patients with pancreatic cancer. Journal of Anesthesia 27(1): 88-92, 2013.
  9. Morimoto A, Winaga H, Sakurai H, Ohmichi M, Yoshimoto T, Ohmichi Y, Matsui T, Ushida T, Okada T, Sato J: Treadmill running and static stretching improve long-lasting hyperalgesia, joint limitation, and muscle atrophy induced by cast immobilization in rats. Nuroscience Letters 534: 295-300, 2013.
  10. Watanabe C, Seino Y, Miyahara H, Yamamoto M, Fukami A, Ozaki N, Takagishi Y, Sato J, Fukuwatari T, Shibata K, Oiso Y, Murata Y , Hayashi Y: Remodeling of hepatic metabolism and hyperaminoacidemia in mice deficient in proglucagon-derived peptides. Diabetes 61: 74−84, 2012.
  11. Mizoguchi H, Yamada K, Nabeshima T: Matrix metalloproteinases contribute to neuronal dysfunction in animal models of drug dependence, Alzheimer's disease, and epilepsy. Biochemistry Research International 2011:681385, 2011.
  12. Naruse K, Sato J, Funakubo M, Hata M, Nakamura N, Kobayashi Y, Kamiya H, Shibata T, Kondo M, Himeno T, Matsubara T, Oiso Y, Nakamura J: Transplantation of bone marrow-derived mononuclear cells improves mechanical hyperalgesia, cold allodynia and nerve function in diabetic neuropathy, PLosOne 6(11): e27485, 2011.
  13. Furukawa-Hibi Y, Alkam T, Nitta A, Matsuyama A, Mizoguchi H, Suzuki K, Moussaoui S, Yu QS, Greig NH, Nagai T, Yamada K: Butyrylcholinesterase inhibitors ameliorate cognitive dysfunction induced by amyloid-β peptide in mice. Behavioural Brain Research 225(1):222-9, 2011.
  14. Sato J, Itano Y, Funakubo M, Mizoguchi H, Itoh M, Mori R: Low barometric pressure aggravates neuropathic pain in guinea pigs. Neuroscience Letters 503(2): 152-156, 2011.
  15. Mizuno T, Doi Y, Mizoguchi H, Jin S, Noda M, Sonobe Y, Takeuchi H, Suzumura A: Interleukin-34 selectively enhances the neuroprotective effects of microglia to attenuate oligomeric amyloid-β neurotoxicity. The American Journal of Pathology 179(4): 2016-27, 2011.
  16. Mizoguchi H, Nakade J, Tachibana M, Ibi D, Someya E, Koike H, Kamei H, Nabeshima T, Itohara S, Takuma K, Sawada M, Sato J, Yamada K: Matrix metalloproteinase-9 contributes to kindled seizure development in pentylenetetrazole-treated mice by converting pro-BDNF to mature BDNF in the hippocampus. The Journal of Neuroscience 31(36): 12963-12971, 2011.
  17. Shichi K, Fujita-Hamabe W, Harada S, Mizoguchi H, Yamada K, Nabeshima T, Tokuyama S: Involvement of matrix metalloproteinase-mediated proteolysis of neural cell adhesion molecule in the development of cerebral ischemic neuronal damage. Journal of Pharmacology and Experimental Therapeutics 338(2): 701-10, 2011.
  18. Mizoguchi H, Ibi D, Takase F, Nagai T, Kamei H, Toth E, Sato J, Takuma K, Yamada K: Nicotine ameliorates impairment of working memory in methamphetamine-treated rats. Behavioural Brain Research 220(1): 159-163, 2011.
  19. Takeuchi H, Mizoguchi H, Doi Y, Jin S, Noda M, Liang J, Li H, Zhou Y, Mori R, Yasuoka S, Li E, Parajuli B, Kawanokuchi J, Sonobe Y, Sato J, Yamanaka K, Sobue G, Mizuno T, Suzumura A: Blockade of gap junction hemichannel suppresses disease progression in mouse models of amyotrophic lateral sclerosis and Alzheimer's disease. PLoS One 6(6): e21108, 2011.
  20. Funakubo M, Sato J, Obata K, Mizumura K: The rate and magnitude of atmospheric pressure change that aggravate pain-related behavior of nerve injured rats. International Journal of Biometeorology 55(3): 319-326, 2011.
  21. Matsubara T, Arai YCP, Shiro Y, Shimo K, Nishihara M, Sato J, Ushida T: Comparative effects of acupressure at local and distal acupuncture points on pain conditions and autonomic function in females with chronic neck pain. Evidence-Based Complementary and Alternative Medicine, 2011 Article ID 543291, 2011.
  22. Mizoguchi H, Fukaya K, Mori R, Itoh M, Funakubo M, Sato J: Lowering barometric pressure aggravates depression-like behavior in rats. Behavioural Brain Research 218(1): 190-193, 2011.
  23. Mizoguchi H, Yamada K: Pharmacologic treatment with GABAB receptor agonist of methamphetamine-induced cognitive impairment in mice. Current Neuropharmacology 9(1): 109-112, 2011.
  24. Sakurai H, Sato J, Yoshimoto T, Ohmichi Y, Morimoto A, Arai YCP, Ushida T: Examination of subjective sensations and vasomotor reaction to environmental temperature changes in chronic pain patients with impaired cold sensation. Pain Research, 26(1): 11-18, 2011.
  25. Messlinger K, Funakubo M, Sato J, Mizumura K :Increases in neuronal activity in rat spinal trigeminal nucleus following changes in barometric pressure-relevance for weather-associated headache. Headache 50(9): 1449-1463, 2010.
  26. Matsubara T, Arai YC, Shimo K, Sato J, Osuga T, Nishihra M, Ushida T: Effects of cognitive-behavioral therapy on pain intensity and level of physical activity in Japanese patients with chronic pain-a preliminary quasi-experimental study. Journal of Physical Therapy 1(2): 49-57, 2010.
  27. Yun J, Koike H, Ibi D, Toth E, Mizoguchi H, Nitta A, Yoneyama M, Ogita K, Yoneda Y, Nabeshima T, Nagai T, Yamada K: Chronic restraint stress impairs neurogenesis and hippocampus-dependent fear memory in mice: possible involvement of a brain-specific transcription factor Npas4. Journal of Neurochemistry 114(6): 1840-1851, 2010.
  28. Alkam T, Nitta A, Furukawa-Hibi Y, Niwa M, Mizoguchi H, Yamada K, Nabeshima T:Oral supplementation with Leu-lle, a hydrophobic dipeptide, prevents the impairment of memory induced by amyloid beta in mice via restraining the hyperphosphorylation of extracellular signal-regulated. Behavioural Brain Research 210(2): 184-190, 2010.
  29. Katsuno M, Adachi H, Minamiyama M, Waza M, Doi H, Kondo N, Mizoguchi H, Nitta A, Yamada K, Banno H, Suzuki K, Tanaka F, Sobue G: Disrupted transforming growth factor-beta signaling in spinal and bulbar muscular atrophy. The Journal of Neuroscience 30(16): 5702-5712, 2010.
  30. Mizoguchi H, Ibi D, Takuma K, Toth E, Sato Jun, Itohara S, Nabeshima T, Yamada K: Alterations of emotional and cognitive behaviors in matrix metalloproteinase-2 and -9-deficient mice. The Open Behavioral Science Journal 4: 19-25, 2010.
  31. Arai PYC, Kandatsu N, Ito H, Sato J, Ushida T, Suetomi K, Nishihara M, Matsubara T, Komatsu T: Behavior of children emerging from general anesthesia correlates with their heart rate variability. Journal of Anesthesia 24(2): 317-318, 2010.

(May 7, 2015)