Research Institute of Environmental Medicine Nagoya University

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Neuroscience I

Staff

Professor
Sayaka Takemoto
Assistant Professor
Shinichiro Horigane
Assistant Professor
Shuhei Ueda
member

Research Projects

Under Construction

Recent publications

  • Takemoto-Kimura S, Horigane S, Kamijo S,Inoue M,Sakamoto M,Fujii H,Bito H*. Calmodulin kinases: essential regulators in health and disease. J Neurochem 141:808-818. doi: 10.1111/jnc.14020. (2017)
  • Horigane S, Ageta-Ishihara N, Kamijo S, Fujii H, Okamura M, Kinoshita M, Takemoto-Kimura S*, Bito H*. Facilitation of axon outgrowth via a Wnt5a-CaMKK-CaMKIalpha pathway during neuronal polarization. Molecular Brain 16;9(1):8. doi:10.1186/s13041-016-0189-3 (2016) (*co-corresponding authors)
  • Inoue M, Takeuchi A, Horigane S, Ohkura M, Gengyo-Ando K, Fujii H, Kamijo S, Takemoto-Kimura S, Kano M, Nakai J, Kitamura K, BitoH: Rational design of a high-affinity, fast, red calcium indicator R-CaMP2. Nat Methods 12(1): 64-70 (2015)
  • Nonaka M, Kim R, Sharry S, Matsushima A, Takemoto-Kimura S, Bito H: Towards a better understanding of cognitive behaviors regulated by gene expression downstream of activity-dependent transcription factors. Neurobiol Learn Mem 115: 21-9 (2014)
  • Nonaka M, Kim R, Fukushima H, Sasaki K, Suzuki K, Okamura M, Ishii Y, Kawashima T, Kamijo S, Takemoto-Kimura S, Okuno H, Kida S, Bito H.: Region-Specific Activation of CRTC1-CREB Signaling Mediates Long-Term Fear Memory. Neuron 84(1): 92-106 (2014)
  • Kawashima T, Kitamura K, Suzuki K, Nonaka M, Kamijo S, Takemoto-Kimura S, Kano M, Okuno H, Ohki K, Bito H. Functional labeling of neurons and their projections using the synthetic activity-dependent promoter E-SARE. Nat Methods 10, 889-895 (2013)
  • Fujii H, Inoue M, Okuno H, Sano Y, Takemoto-Kimura S, Kitamura K, Kano M, Bito H. Nonlinear decoding and asymmetric representation of neuronal input information by CaMKIIα and calcineurin. Cell Rep 3, 978-987 (2013)
  • Okuno H, Akashi K, Ishii Y, Yagishita-Kyo N, Suzuki K, Nonaka M, Kawashima T, Fujii H, Takemoto-Kimura S, Abe M, Natsume R, Chowdhury S, Sakimura K, Worley PF and Bito H. Inverse Synaptic Tagging of Inactive Synapses via Dynamic Interaction of Arc/Arg3.1 with CaMKIIbeta. Cell 149, 886-898 (2012)
  • Ageta-Ishihara N, Takemoto-Kimura S, Nonaka M, Adachi-Morishima A, Suzuki K, Kamijo S, Fujii H, Mano T, Blaeser F, Chatila TA, Mizuno H, Hirano T, Tagawa Y, Okuno H and Bito H. Control of cortical axon elongation by a GABA-driven Ca2+/calmodulin-dependent protein kinase cascade. J Neurosci 29, 13720-13729 (2009)
  • Kawashima T, Okuno H, Nonaka M, Adachi-Morishima A, Kyo N, Okamura M, Takemoto-Kimura S, Worley PF and Bito H. Synaptic activity-responsive element in the Arc/Arg3.1 promoter essential for synapse-to-nucleus signaling in activated neurons. Proc Natl Acad Sci USA 106, 316-321 (2009)
  • Bito H, Takemoto-Kimura S, Okuno H. Activity-dependent gene regulation: How do synapses talk to the nucleus and fine-tune neuronal outputs? in “Molecular Pain“. (M. Zhuo ed., Springer, New York), 207-217 (2008)
  • Takemoto-Kimura S, Ageta-Ishihara N, Nonaka M, Adachi-Morishima A, Mano T, Okamura M, Fujii H, Fuse T, Hoshino M, Suzuki S, Kojima M, Mishina M, Okuno H and Bito H. Regulation of dendritogenesis via a lipid-raft-associated Ca2+/calmodulin-dependent protein kinase CLICK-III/CaMKIgamma. Neuron 54, 755-770 (2007)
  • Fuse T, Ohmae S, Takemoto-Kimura S, Bito H. DCLK1. AfCS/Nature Molecule Pages, doi:10.1038/mp.a003011.01 (2007)
  • Sato K, Suematsu A, Nakashima T, Takemoto-Kimura S, Aoki K, Morishita Y, Asahara H, Ohya K, Yamaguchi A, Takai T, Kodama T, Chatila TA, Bito H and Takayanagi H. Regulation of osteoclast differentiation and function by the CaMK-CREB pathway. Nat Methods 12, 1410-1416 (2006)
  • Ohmae S, Takemoto-Kimura S, Okamura M, Adachi-Morishima A., Nonaka M, Fuse T, Kida S, Tanji M, Furuyashiki T, Arakawa Y, Narumiya S, Okuno H and Bito H. Molecular identification and characterization of a family of kinases with homology to Ca2+/calmodulin-dependent protein kinases I/IV. J Biol Chem 281, 20427-20439 (2006)
  • Nonaka M, Doi T, Fujiyoshi Y, Takemoto-Kimura S and Bito H. Essential contribution of the ligand-binding beta B/beta C loop of PDZ1 and PDZ2 in the regulation of postsynaptic clustering, scaffolding, and localization of postsynaptic density-95. J Neurosci 26, 763-774 (2006)
  • Takemoto-Kimura S, Terai H, Takamoto M, Ohmae S, Kikumura S, Segi E, Arakawa Y, Furuyashiki T, Narumiya S and Bito H. Molecular cloning and characterization of CLICK-III/CaMKIgamma, a novel membrane-anchored neuronal Ca2+/calmodulin-dependent protein kinase (CaMK). J Biol Chem 278, 18597-18605 (2003)
  • Arakawa Y, Bito H, Furuyashiki T, Tsuji T, Takemoto-Kimura S, Kimura K, Nozaki K, Hashimoto N and Narumiya S. Control of axon elongation via an SDF-1alpha/Rho/mDia pathway in cultured cerebellar granule neurons. J Cell Biol 161, 381-391 (2003)
  • Bito H and Takemoto-Kimura S. Ca2+/CREB/CBP-dependent gene regulation: a shared mechanism critical in long-term synaptic plasticity and neuronal survival. Cell Calcium 34, 425-430 (2003)
  • Furuyashiki T, Arakawa Y, Takemoto-Kimura S, Bito H and Narumiya S. Multiple spatiotemporal modes of actin reorganization by NMDA receptors and voltage-gated Ca2+ channels. Proc Natl Acad Sci USA 99, 14458-14463 (2002)