Research Institute of Environmental Medicine Nagoya University

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RaQualia Pharma Industry-Academia Collaborative Research Center
(Pharmacology, Pharmaceutical Sciences)

Staff

Director of Center
Professor
Makoto Sawada
Department of Pharmacology
Designated Professor
Hyi-Man Park
Designated Assistant Professor
Yukiko Moriguchi
Designated Assistant Professor
Akiyoshi Fujiuchi
Designated Assistant Professor
Koichi Oishi
Department of Pharmaceutical Sciences
Designated Associate Professor
Mikio Morita
Designated Assistant Professor
Kiyoshi Kawamura
Designated Assistant Professor
Tatsuya Yamagishi

Research Projects

RaQualia Pharma Industry-Academia Collaborative Research Center (RARC) was founded in 2018 under Research Institute of Environmental Medicine (RIEM) to develop new medicines by collaboration between RaQualia Pharma Inc. and Nagoya University. RARC tightly collaborates with Graduate School of Medicine and Graduate School of Pharmaceutical Sciences, which enable cross sectional drug discovery research at Nagoya University. Drug discovery research is implemented in the two departments.

Department of Pharmacology

We establish screening assays and pharmacological models to assess drug candidate molecules. Namely, we identify the molecular targets including ion-channels, and establish high throughput screening assays. We evaluate newly synthesized molecular entities by Department of Pharmaceutical Sciences with the established in vitro/in vivo assays, and assess ADMET (Absorption, Distribution, Metabolism, Excretion, and Toxicity) profiles.

Department of Pharmaceutical Sciences

We synthesize new drug candidates based on the hit compounds identified by screening of compound library. To design new molecules, we apply computational chemistry approach having the structure information. Intensive SAR (Structure-Activity Relationship´╝ë studies are implemented by systematically analyzing the pharmacological data which are quickly fed back from Department of Pharmacology.

Recent publications

  • Oya M, Suzuki H, Anas ARJ, Oishi K, Ono K, Yamaguchi S, Eguchi M, Sawada M. LC-MS/MS imaging with thermal film-based laser microdissection. Anal Bioanal Chem. 410: 491-499, 2018.
  • Yamada K, Levell J, Yoon T, Kohls D, Yowe D, Rigel D, Imase H, Yuan J, Yasoshima K, DiPetrillo K, Monovich L, Xu L, Zhu M, Kato M, Jain M, Idamakanti N, Taslimi P, Kawanami T, A. Argikar U, Kunjathoor V, Xie X, Yagi Y, Iwaki Y, Robinson Z, and Park HM. Optimization of allosteric With-No-Lysine (WNK) kinase inhibitors and efficacy in rodent hypertension models. J. Med. Chem. 60: 7099-7107, 2017.
  • Okumura Y, Yamagishi T, Nukui S, Nakao K. Discovery of AAT-008, a novel, potent, and selective prostaglandin EP4 receptor antagonist. Bioorg. Med. Chem. Lett. 27: 1186-1192, 2017.
  • Yamada K, Zhang J-H, Xie X, Reinhardt J, Xie A, LaSala D, Kohls D, Yowe D, Burdick D, Yoshisue H, Wakai H, Schmidt I, Gunawan J, Yasoshima K, Yue K, Kato M, Mogi M, Idamakanti N, Kreder N, Drueckes P, Pandey P, Kawanami T, Huang W, Yagi Y, Deng Z, Park HM. Discovery and characterization of allosteric WNK kinase inhibitors. ACS Chem. Biol. 11: 3338-3346, 2016.
  • Yamada K*, Park HM*, Rigel D*, DiPetrillo K*, Whalen E*, Anisowicz A, Beil M, Berstler J, Brocklehurst C, Burdick D, Caplan S, Capparelli M, Chen G, Chen W, Dale B, Deng L, Fu F, Hamamatsu N, Harasaki K, Herr T, Hoffmann T, Hu Q, Huang W, Idamakanti N, Imase H, Iwaki Y, Jain M, Jeyaseelan J, Kato M, Kaushik V, Kohls D, Kunjathoor V, LaSala D, Lee J, Liu J, Luo Y, Ma F, Mo R, Mowbray S, Mogi M, Ossola F, Pandey P, Patel S, Raghavan S, Salem B, Shanado Y, Trakshel G, Turner G, Wakai H, Wang C, Weldon S, Wielicki J, Xie X, Xu L, Yagi Y, Yasoshima Y, Yin J, Yowe D, Zhang J, Zheng G, Monovich L*. Small molecule WNK inhibition regulates cardiovascular and renal function. Nat. Chem. Biol. 12: 896-898, 2016. * Equal contribution
  • Morita H, Mochiki E, Takahashi N, Kawamura K, Watanabe A, Sutou, T, Ogawa, A, Yanai, M, Ogata, K, Fujii, T. Effects of 5-HT2B, 5-HT3 and 5-HT4 receptor antagonist on gastrointestinal motor activity in dogs. World J. Gastroenterol. 19: 6604-6612, 2013.
  • Tsutsumi K, Kasaoka T, Park HM, Nishiyama H, Nakajima M, Honda T. Tumor growth inhibition by synthetic and expressed siRNA targeting focal adhesion kinase. Int. J. Oncol. 33: 215-224, 2008.
  • Onoue S, Kawamura K, Igarashi N, Zhou Y, Fujikawa M, Yamada H, Tsuda Y, Seto Y, Yamada S. Reactive oxygen species assay-based risk assessment of drug-induced phototoxicity: classification criteria and application to drug candidates. J. Pharm. Biomed. Anal. 47: 967-972, 2008.
  • Kanai Y, Nakazato E, Fujiuchi A, Hara T, Imai A. Involvement of an increased spinal TRPV1 sensitization through its up-regulation in mechanical allodynia of CCI rats. Neuropharmaology. 49: 977-984, 2005.

(June 19, 2018)