The astrocytic ensemble acts as a multiday trace to stabilize memory.
Dewa KI, Kaseda K, Kuwahara A, Kubotera H, Yamazaki A, Awata N, Komori A, Holtz MA, Kasai A,Skibbe H, Takata N, Yokoyama T, Tsuda M, Numata G, Nakamura S, Takimoto E, Sakamoto M, Ito M, Masuda T & Jun Nagai.
Nature. 2025 Oct;15. doi: 10.1038/s41586-025-09619-2

Recovery of centralities in medial prefrontal and sensory-related cortices associated with social behavior improvements in an autism mouse model.
Ueno H, Iyanaga Y, Kunida K, Hara Y, Miura H, Nakai Y, Tanuma M, Hayashida M, Yokoyama R, Ohkubo J, Seiriki K, Hayata-Takano A, Ao T, Yamaguchi S, Kitaoka S, Furuyashiki T, Ago Y, Nakazawa T, Takuma K, Yoshimoto J, Hashimoto H & Kasai A.
Sci Rep. 2025 July;15：22895. doi: 10.1038/s41598-025-05996-w

Socially activated neurons in the anterior cingulate cortex are essential for social behavior in mice.
Kitagawa K, Takemoto T, Seiriki K, Kasai A, Hashimoto H, Nakazawa T.
Biochem Biophys Res Commun. 2024 Sep 24;726:150251.doi: 10.1016/j.bbrc.2024.150251.

Optimization of AAV vectors for transactivator-regulated gene expression within targeted neuronal populations.
Kojima L, Seiriki K, Rokujo H, Nakazawa T, Kasai A, Hashimoto H.
iScience. 2024 May 3;27(6):109878. doi: 10.1016/j.isci.2024.109878.

(R)-ketamine restores anterior insular cortex activity and cognitive deficits in social isolation-reared mice.
Yokoyama R, Ago Y, Igarashi H, Higuchi M, Tanuma M, Shimazaki Y, Kawai T, Seiriki K, Hayashida M, Yamaguchi S, Tanaka H, Nakazawa T, Okamura Y, Hashimoto K, Kasai A, Hashimoto H.
Mol Psychiatry. 2024 May;29(5):1406-1416. doi: 10.1038/s41380-024-02419-6.

Clozapine induces neuronal activation in the medial prefrontal cortex in a projection target-based manner.
Hirato Y, Seiriki K, Kojima L, Yamada S, Rokujo H, Takemoto T, Nakazawa T, Kasai A, Hashimoto H.
Biol Pharm Bull. 2024;47(2):478-485. doi: 10.1248/bpb.b23-00898.

Long-lasting anti-despair and anti-anhedonia effects of (S)-norketamine in social isolation-reared mice.
Yokoyama R, Higuchi M, Tanabe W, Tsukada S, Igarashi H, Seiriki K, Nakazawa T, Kasai A, Ago Y, Hashimoto H.
J Pharmacol Sci. 2024 Feb;154(2):72-76. doi: 10.1016/j.jphs.2023.12.005.

Activity-dependent organization of prefrontal hub-networks for associative learning and signal transformation.
Agetsuma M, Sato I, Tanaka YR, Carrillo-Reid L, Kasai A, Noritake A, Arai Y, Yoshitomo M, Inagaki T, Yukawa H, Hashimoto H, Junichi Nabekura, Nagai T.
Nat Commun. 2023 Oct 6;14(1):5996. doi: 10.1038/s41467-023-41547-5.

Decreased expression EP3 receptor mRNA in the brain of mouse model of autisum spectrum disorder.
Anggadiredja K, Kurniati NF, Kasai A, Hashimoto H.
Microrna. 2023;12(3):221-226. doi: 10.2174/2211536612666230427152647.

Dorsal raphe serotonergic neurons preferentially reactivate dorsal dentate gyrus cell ensembles associated with positive experience.
Nagai Y, Kisaka Y, Nomura K, Nishitani N, Andoh C, Koda M, Kawai H, Seiriki K, Nagayasu K, Kasai A, Shirakawa H, Nakazawa T, Hashimoto H, Kaneko S.
Cell Rep. 2023 Mar 28;42(3):112149. doi: 10.1016/j.celrep.2023.112149.

High-throughput line-illumination Raman microscopy using multislit detection.
Mochizuki K, Kumamoto Y, Maeda S, Tanuma M, Kasai A, Takemura M, Harada Y, Hashimoto H, Tanaka H, Smith NI, Fujita K.
Biomed Opt Express. 2023 Feb 7;14(3):1015-1026. doi: 10.1364/BOE.480611.

Pre-treatment of oncolytic reovirus improves tumor accumulation and intratumoral distribution of PEG-liposomes.
Eguchi M, Hirata S, Ishigami I, Shuwari N, Ono R, Tachibana M, Tanuma M, Kasai A, Hashimoto H, Ogawara KI, Mizuguchi H, Sakurai F.
J Control Release. 2023 Feb;354:35-44. doi: 10.1016/j.jconrel.2022.12.050.

Parabrachial-to-parasubthalamic nucleus pathway mediates fear-induced suppression of feeding in male mice.
Nagashima T, Tohyama S, Mikami K, Nagase M, Morishima M, Kasai A, Hashimoto H, Watabe AM.
Nat Commun. 2022 Dec 30;13(1):7913. doi: 10.1038/s41467-022-35634-2.

Acute social defeat stress activates neurons project to the claustrum and basolateral amygdala.
Tanuma M, Niu M, Ohkubo J, Ueno H, Nakai Y, Yokoyama Y, Seiriki K, Hashimoto H, Kasai A.
Mol Brain. 2022 Dec 20;15(1):100. doi: 10.1186/s13041-022-00987-8.

Molecular basis of astrocyte diversity and morphology across the CNS in health and disease.
Endo F, Kasai A, Soto JS, Yu X, Hashimoto H, Qu Z, Gradinaru V, Kawaguchi R, Khakh BS.
Science. 2022 Nov 4;378(6619):eadc9020. doi: 10.1126/science.adc9020.

Oxytocin ameliorates impaired social behavior in a mouse model of 3q29 deletion syndrome.
Takemoto T, Baba M, Yokoyama K, Kitagawa K, Nagayasu K, Ago Y, Seiriki K, Hayata-Takano A, Kasai A, Mori D, Ozaki N, Takuma K, Hashimoto R, Hashimoto H, Nakazawa T.
Mol Brain. 2022 Mar 28;15(1):26. doi: 10.1186/s13041-022-00915-w.

Claustrum mediates bidirectional and reversible control of stress-induced anxiety responses.
Niu M, Kasai A, Tanuma M, Seiriki K, Igarashi H, Kuwaki T, Nagayasu K, Miyaji K, Ueno H, Tanabe W, Seo K, Yokoyama R, Ohkubo J, Ago Y, Hayashida M, Inoue KI, Takada M, Yamaguchi S, Nakazawa T, Kaneko S, Okuno H, Yamanaka A, Hashimoto H.
Sci Adv. 2022 Mar 18;8(11):eabi6375. doi: 10.1126/sciadv.abi6375.

Multiple alterations in glutamatergic transmission and dopamine D2 receptor splicing in induced pluripotent stem cell-derived neurons from patients with familial schizophrenia.
Yamamoto K, Kuriu T, Matsumura K, Nagayasu K, Tsurusaki Y, Miyake N, Yamamori H, Yasuda Y, Fujimoto M, Fujiwara M, Baba M, Kitagawa K, Takemoto T, Gotoda-Nishimura N, Takada T, Seiriki K, Hayata-Takano A, Kasai A, Ago Y, Kida S, Takuma K, Ono F, Matsumoto N, Hashimoto R, Hashimoto H, Nakazawa T.
Transl Psychiatry. 2021 Oct 25;11(1):548. doi: 10.1038/s41398-021-01676-1.

Taro Ichimura, Taishi Kakizuka, Kazuki Horikawa, Seiriki K, Kasai A, Hashimoto H, Fujita K, Tomonobu M. Watanabe, Nagai T. Trans-scale-scope to explore rare cellular activities in more than one million cells. Sci Rep, 11:16539 (2021)

Comprehensive characterization of migration profiles of murine cerebral cortical neurons during development using FlashTag labeling.
Yoshinaga S, Shin M, Kitazawa A, Ishii K, Tanuma M, Kasai A, Hashimoto H, Kubo KI, Nakajima K.
iScience. 2021 Mar 6;24(4):102277. doi: 10.1016/j.isci.2021.102277.

Intranasal oxytocin administration ameliorates social behavioral deficits in POGZWT/Q1038R mouse model of autism spectrum disorder.
Kitagawa K, Matsumura K, Baba M, Kondo M, Takemoto T, Nagayasu K, Ago Y, Seiriki K, Hayata-Takano A, Kasai A, Takuma K, Hashimoto R, Hashimoto H, Nakazawa T.
Mol Brain. 2021 Mar 16;14(1):56. doi: 10.1186/s13041-021-00769-8.

Altered functional connectivity of the orbital cortex and striatum associated with catalepsy induced by dopamine D1 and D2 receptor antagonists.
Niu M, Kasai A, Seiriki K, Hayashida M, Tanuma M, Yokoyama R, Hirato Y, Hashimoto H.
Biol Pharm Bull. 2021;44(3):442-447. doi: 10.1248/bpb.b20-01006.

Lipocalin-type prostaglandin D synthase regulates light-induced phase advance of the central circadian rhythm in mice.
Kawaguchi C, Shintani N, Hayata-Takano A, Hatanaka M, Kuromi A, Nakamura R, Yamano Y, Shintani Y, Nagai K, Tsuchiya S, Sugimoto Y, Ichikawa A, Okuno Y, Urade Y, Hirai H, Nagata KY, Narumiya S, Nakazawa T, Kasai A, Ago Y, Takuma K, Baba A, Hashimoto H.
Commun Biol. 2020 Oct 8;3(1):557. doi: 10.1038/s42003-020-01281-w.

(S)-norketamine and (2S,6S)-hydroxynorketamine exert potent antidepressant-like effects in a chronic corticosterone-induced mouse model of depression.
Yokoyama R, Higuchi M, Tanabe W, Tsukada S, Naito M, Yamaguchi T, Chen L, Kasai A, Seiriki K, Nakazawa T, Nakagawa S, Hashimoto K, Hashimoto H, Ago Y.
Pharmacol Biochem Behav. 2020 Apr;191:172876. doi: 10.1016/j.pbb.2020.172876.

Direct visualization of an antidepressant analog using surface-enhanced Raman scattering in the brain.
Tanuma M, Kasai A, Bando, Kotoku N, Harada K, Minoshima M, Higashino K, Kimishima A, Arai M, Ago Y, Seiriki K, Kikuchi K, Kawata S, Fujita K, Hashimoto H.
JCI Insight. 2020 Mar 26;5(6):e133348. doi: 10.1172/jci.insight.133348.

Pathogenic POGZ mutation causes impaired cortical development and reversible autism-like phenotypes.
Matsumura K, Seiriki K, Okada S, Nagase M, Ayabe S, Yamada I, Furuse T, Shibuya H, Yasuda Y, Yamamori H, Fujimoto M, Nagayasu K, Yamamoto K, Kitagawa K, Miura H, Gotoda-Nishimura N, Igarashi H, Hayashida M, Baba M, Kondo M, Hasebe S, Ueshima K, Kasai A, Ago Y, Hayata-Takano A, Shintani N, Iguchi T, Sato M, Yamaguchi S, Tamura M, Wakana S, Yoshiki A, Watabe AM, Okano H, Takuma K, Hashimoto R, Hashimoto H, Nakazawa T.
Nat Commun. 2020 Feb 26;11(1):859. doi: 10.1038/s41467-020-14697-z.

Autism-associated protein kinase D2 regulates embryonic cortical neuron development.
Matsumura K, Baba M, Nagayasu K, Yamamoto K, Kondo M, Kitagawa K, Takemoto T, Seiriki K, Kasai A, Ago Y, Hayata-Takano A, Shintani N, Kuriu T, Iguchi T, Sato M, Takuma K, Hashimoto R, Hashimoto H, Nakazawa T.
Biochem Biophys Res Commun. 2019 Nov 12;519(3):626-632. doi: 10.1016/j.bbrc.2019.09.048.

(R)-ketamine induces a greater increase in prefrontal 5-HT release than (S)-ketamine and ketamine metabolites via an AMPA receptor-independent mechanism.
Ago Y, Tanabe W, Higuchi M, Tsukada S, Tanaka T, Igarashi H, Yamaguchi T, Nakagawa S, Seiriki K, Kasai A, Nakazawa T, Hashimoto K, Hashimoto H.
Int J Neuropsychopharmacol. 2019 Oct 1;22(10):665-674. doi: 10.1093/ijnp/pyz041.

Psychiatric-disorder-related behavioral phenotypes and cortical hyperactivity in a mouse model of 3q29 deletion syndrome.
Baba M, Yokoyama K, Seiriki K, Naka Y, Matsumura K, Kondo M, Yamamoto K, Hayashida M, Kasai A, Ago Y, Nagayasu K, Hayata-Takano A, Takahashi A, Yamaguchi S, Mori D, Ozaki N, Yamamoto T, Takuma K, Hashimoto R, Hashimoto H, Nakazawa T.
Neuropsychopharmacology. 2019 Nov;44(12):2125-2135. doi: 10.1038/s41386-019-0441-5.

Pituitary adenylate cyclase-activating polypeptide modulates dendritic spine maturation and morphogenesis via microRNA-132 upregulation.
Hayata-Takano A, Kamo T, Kijima H, Seiriki K, Ogata K, Ago Y, Nakazawa T, Shintani Y, Higashino K, Nagayasu K, Shintani N, Kasai A, Waschek JA, Hashimoto H.
J Neurosci. 2019 May 29;39(22):4208-4220. doi: 10.1523/JNEUROSCI.2468-18.2019.

Whole-brain block-face serial microscopy tomography at subcellular resolution using FAST.
Seiriki K, Kasai A, Nakazawa T, Niu M, Naka Y, Tanuma M, Igarashi H, Yamaura K, Hayata-Takano A, Ago Y, Hashimoto H.
Nat Protoc. 2019 May;14(5):1509-1529. doi: 10.1038/s41596-019-0148-4.

mS-11, a mimetic of the mSin3-binding helix in NRSF, ameliorates social interaction deficits in a prenatal valproic acid-induced autism mouse model.
Kawase H, Ago Y, Megumi Naito, Higuchi M, Hara Y, Hasebe S, Tsukada S, Kasai A, Nakazawa T, Mishina T, Kouji H, Takuma K, Hashimoto H.
Pharmacol Biochem Behav. 2019 Jan;176:1-5. doi: 10.1016/j.pbb.2018.11.003.

Saturated excitation microscopy using differential excitation for efficient detection of nonlinear fluorescence signals.
Nawa Y, Yonemaru Y, Kasai A, Oketani R, Hashimoto H, Smith NI, Fujita K.
APL Photonics. 2018 Aug;3:080805. doi: 10.1063/1.5039567.

β-Arrestin1 and 2 differentially regulate PACAP-induced PAC1 receptor signaling and trafficking.
Shintani Y, Hayata-Takano A, Moriguchi K, Nakazawa T, Ago Y, Kasai A, Seiriki K, Shintani N, Hashimoto H.
PLoS One. 2018 May 7;13(5):e0196946. doi: 10.1371/journal.pone.0196946.

Knockdown of the mitochondria-localized protein p13 protects against experimental parkinsonism.
Inoue N, Ogura S, Kasai A, Nakazawa T, Ikeda K, Higashi S, Isotani A, Baba K, Mochizuki H, Fujimura H, Ago Y, Hayata-Takano A, Seiriki K, Shintani Y, Shintani N, Hashimoto H.
EMBO Rep. 2018 Mar;19(3):e44860. doi: 10.15252/embr.201744860.

Unbiased compound screening with a reporter gene assay highlights the role of p13 in the cardiac cellular stress response.
Inoue N, Hirouchi T, Kasai A, Higashi S, Hiraki N, Tanaka S, Nakazawa T, Nunomura K, Lin B, Omori A, Ikeda K, Hayata-Takano A, Kim YJ, Doi T, Baba A, Hashimoto H, Shintani N.
Biochem Biophys Res Commun. 2018 Jan 8;495(2):1992-1997. doi: 10.1016/j.bbrc.2017.11.116.

High-speed imaging and scalable whole-brain imaging in rodents and primates.
Seiriki K, Kasai A, Hashimoto T, Schulze W, Niu M, Yamaguchi S, Nakazawa T, Inoue KI, Uezono S, Takada M, Naka Y, Igarashi H, Tanuma M, Waschek JA, Ago Y, Tanaka KF, Hayata-Takano A, Nagayasu K, Shintani N, Hashimoto R, Kunii Y, Hino M, Matsumoto J, Yabe H, Nagai T, Fujita K, Matsuda T, Takuma K, Baba A, Hashimoto H.
Neuron. 2017 Jun 21;94(6):1085-1100.e6. doi: 10.1016/j.neuron.2017.05.017.

Differential gene expression profile in neurons from a monozygotic twin of patients with treatment resistant schizophrenia discordant for clozapine response.
Nakazawa T, Kikuchi M, Ishikawa M, Yamamori H, Nagayasu K, Matsumoto T, Fujimoto M, Yasuda Y, Fujiwara M, Okada S, Matsumura K, Kasai A, Hayata-Takano A, Shintani N, Numata S, Takuma K, Akamatsu W, Okano H, Nakaya A, Hashimoto H, Hashimoto R.
Schizophr Res. 2017 Mar;181:75-82. doi: 10.1016/j.schres.2016.10.012.

Double in situ hybridization for detecting microRNAs and mRNAs in brain tissues.
Kasai A, Kakihara S, Miura H, Okada R, Hazama K, Nakazawa T, Hayata-Takano A, Niu M, Shintani N, Hashimoto H.
Front Mol Neurosci. 2016 Nov 22;9:126. doi: 10.3389/fnmol.2016.00126.

Critical involvement of the orbitofrontal cortex in hyperlocomotion induced by NMDA receptor blockade in mice.
Seiriki K, Kasai A, Kuwaki T, Nakazawa T, Yamaguchi S, Hashimoto H.
Biochem Biophys Res Commun. 2016 Nov 25;480(4):558-563. doi: 10.1016/j.bbrc.2016.10.089.

Prostaglandin D2 signaling mediated by the CRTH2 receptor is involved in MK-801-induced cognitive dysfunction.
Onaka Y, Shintani N, Nakazawa T, Kanoh T, Ago Y, Matsuda T, Hashimoto R, Ohi K, Hirai H, Nagata KY, Nakamura M, Kasai A, Hayata-Takano A, Nagayasu K, Takuma K, Ogawa A, Baba A, Hashimoto H.
Behav Brain Res. 2016 Nov 1;314:77-86. doi: 10.1016/j.bbr.2016.07.050.

Deletion of JMJD2B in neurons leads to defective spine maturation, hyperactive behavior and memory deficits in mouse.
Fujiwara K, Fujita Y, Kasai A, Onaka Y, Hashimoto H, Yamashita T.
Transl Psychiatry. 2016 Mar 29;6(3):e766. doi: 10.1038/tp.2016.31.

De novo POGZ mutations in sporadic autism disrupt the DNA-binding activity of POGZ.
Matsumura K, Nakazawa T, Nagayasu K, Gotoda-Nishimura N, Kasai A, Hayata-Takano A, Shintani N, Yamamori H, Yasuda Y, Hashimoto R, Hashimoto H.
J Mol Psychiatry. 2016 Apr 21;4:1. doi: 10.1186/s40303-016-0016-x.

Dopamine inhibits lipopolysaccharide-induced nitric oxide production through the formation of dopamine quinone in murine microglia BV-2 cells.
Yoshioka Y, Sugino Y, Tozawa A, Yamamuro A, Kasai A, Ishimaru Y, Maeda S.
J Pharmacol Sci. 2016 Feb;130(2):51-9. doi: 10.1016/j.jphs.2015.11.002.

Myeloid cell-derived LRG attenuates adverse cardiac remodeling after myocardial infarction.
Kumagai S, Nakayama H, Fujimoto M, Honda H, Serada S, Ishibashi-Ueda H, Kasai A, Obana M, Sakata Y, Sawa Y, Fujio Y, Naka T.
Cardiovasc Res. 2016 Feb 1;109(2):272-82. doi: 10.1093/cvr/cvv273.

Whole-exome sequencing and neurite outgrowth analysis in autism spectrum disorder.
Hashimoto R, Nakazawa T, Tsurusaki Y, Yasuda Y, Nagayasu K, Matsumura K, Kawashima H, Yamamori H, Fujimoto M, Ohi K, Umeda-Yano S, Fukunaga M, Fujino H, Kasai A, Hayata-Takano A, Shintani N, Takeda M, Matsumoto N, Hashimoto H.
J Hum Genet. 2016 Mar;61(3):199-206. doi: 10.1038/jhg.2015.141.

Structured line illumination Raman microscopy.
Watanabe K, Palonpon AF, Smith NI, Chiu LD, Kasai A, Hashimoto H, Kawata S, Fujita K.
Nat Commun. 2015 Dec 2;6:10095. doi: 10.1038/ncomms10095.

Comparative gene expression profiles in pancreatic islets associated with Agouti yellow mutation and PACAP overexpression in mice.
Ikeda K, Tomimoto S, Tsuchiya S, Hamagami KI, Shintani N, Sugimoto Y, Ichikawa A, Kasai A, Nakazawa T, Nagayasu K, Ago Y, Onaka Y, Hayata-Takano A, Baba A, Hashimoto H.
Biochem Biophys Rep. 2015 Jun 24;2:179-183. doi: 10.1016/j.bbrep.2015.06.006.

p13 overexpression in pancreatic β-cells ameliorates type 2 diabetes in high-fat-fed mice.
Higashi S, Katagi K, Shintani N, Ikeda K, Sugimoto Y, Tsuchiya S, Inoue N, Tanaka S, Koumoto M, Kasai A, Nakazawa T, Hayata-Takano A, Hamagami K, Tomimoto S, Yoshida T, Ohkubo T, Nagayasu K, Ago Y, Onaka Y, Hashimoto R, Ichikawa A, Baba A, Hashimoto H.
Biochem Biophys Res Commun. 2015 Jun 12;461(4):612-7. doi: 10.1016/j.bbrc.2015.04.074.

Atomoxetine reverses locomotor hyperactivity, impaired novel object recognition, and prepulse inhibition impairment in mice lacking pituitary adenylate cyclase-activating polypeptide (PACAP).
Shibasaki Y, Hayata-Takano A, Hazama K, Nakazawa T, Shintani N, Kasai A, Nagayasu K, Hashimoto R, Tanida M, Katayama T, Matsuzaki S, Yamada K, Taniike M, Onaka Y, Ago Y, Waschek JA, Köves K, Reglodi D, Tamas A, Matsuda T, Baba A, Hashimoto H.
Neuroscience. 2015 Jun 25:297:95-104. doi: 10.1016/j.neuroscience.2015.03.062.

A Mouse Model of Human Primitive Neuroectodermal Tumors Resulting from Microenvironmentally-Driven Malignant Transfromation of Orthotopically Transplanted Radial Glial Cells.
Malchenko S, Sredni ST, Hashimoto H, Kasai A, Nagayasu K, Xie J, Margaryan NV, Seiriki K, Lulla RR, Seftor RE, Pachman LM, Meltzer HY, Hendrix MJ, Soares MB.
PLoS One. 2015 Mar 31;10(3):e0121707. doi: 10.1371/journal.pone.0121707.

Simultaneous neuron- and astrocyte-specific fluorescent marking.
Schultze W, Hayata-Takano A, Kamo T, Nakazawa T, Nagayasu K, Kasai A, Seiriki K, Shintani N, Ago Y, Farfan C, Hashimoto R, Baba A, Hashimoto H.
Biochem Biophys Res Commun. 2015 Mar 27;459(1):81-6. doi: 10.1016/j.bbrc.2015.02.073.

CRTH2, a prostaglandin D2 receptor, mediates depression-related behavior in mice.
Onaka Y, Shintani N, Nakazawa T, Haba R, Ago Y, Wang H, Kanoh T, Hayata-Takano A, Hirai H, Nagata KY, Nakamura M, Hashimoto R, Matsuda T, Waschek JA, Kasai A, Nagayasu K, Baba A, Hashimoto H.
Behav Brain Res. 2015 May 1;284:131-7. doi: 10.1016/j.bbr.2015.02.013.

PACAP enhances axon and neurite outgrowth in cultured hippocampal neurons to a comparable extent as BDNF.
Ogata K, Shintani N, Hayata-Takano A, Kamo T, Higashi S, Seiriki K, Momosaki H, Vaudry D, Vaudry H, Galas L, Kasai A, Nagayasu K, Nakazawa T, Hashimoto R, Ago Y, Matsuda T, Baba A, Hashimoto H.
PLoS One. 2015 Mar 25;10(3):e0120526. doi: 10.1371/journal.pone.0120526

Identification of the role of bone morphogenetic protein (BMP) and transforming growth factor-β (TGF-β) signaling in the trajectory of serotonergic differentiation in a rapid assay in mouse embryonic stem cells in vitro.
Yamasaki A, Kasai A, Toi A, Kurita M, Kimoto S, Hayata-Takano A, Nakazawa T, Nagayasu K, Shintani N, Hashimoto R, Ito A, Meltzer HY, Ago Y, Waschek JA, Onaka Y, Matsuda T, Baba A, Hashimoto H.
J Neurochem. 2015 Feb;132(4):418-28. doi: 10.1111/jnc.12999.

Increased behavioral and neuronal responses to a hallucinogenic drug in PACAP heterozygous mutant mice.
Hazama K, Hayata-Takano A, Uetsuki K, Kasai A, Encho N, Shintani N, Nagayasu K, Hashimoto R, Reglodi D, Miyakawa T, Nakazawa T, Baba A, Hashimoto H.
PLoS One. 2014 Feb 20;9(2):e89153. doi: 10.1371/journal.pone.0089153

Central CRTH2, a second prostaglandin D2 receptor, mediates emotional impairment in the lipopolysaccharide and tumor-induced sickness behavior model.
Haba R, Shintani N, Onaka Y, Kanoh T, Wang H, Takenaga R, Hayata A, Hirai H, Nagata KY, Nakamura M, Kasai A, Hashimoto R, Nagayasu K, Nakazawa T, Hashimoto H, Baba A.
J Neurosci. 2014 Feb 12;34(7):2514-23. doi: 10.1523/JNEUROSCI.1407-13.2014.

Targeted STAT3 disruption in myeloid cells alters immunosuppressor cell abundance in a murine model of spontaneous medulloblastoma.
Abad C, Nobuta H, Li J, Kasai A, Yong WH, Waschek JA.
J Leukoc Biol. 2014 Feb;95(2):357-67. doi: 10.1189/jlb.1012531.

Laser-induced choroidal neovascularization in mice attenuated by deficiency in the apelin-APJ system.
Hara C, Kasai A, Gomi F, Satooka T, Sakimoto S, Nakai K, Yoshioka Y, Yamamuro A, Maeda S, Nishida K.
Invest Ophthalmol Vis Sci. 2013 Jun 21;54(6):4321-9. doi: 10.1167/iovs.13-11611.

Inhibition of apelin expression switches endothelial cells from proliferative to mature state in pathological retinal angiogenesis.
Kasai A, Ishimaru Y, Higashino K, Kobayashi K, Yamamuro A, Yoshioka Y, Maeda S.
Angiogenesis. 2013 Jul;16(3):723-34. doi: 10.1007/s10456-013-9349-6.

Performance of cell-penetrating peptide-linked polymers physically mixed with poorly membrane-permeable molecules on cell membranes.
Sakuma S, Suita M, Yamamoto T, Masaoka Y, Kataoka M, Yamashita S, Nakajima N, Shinkai N, Yamauchi H, Hiwatari K, Hashizume A, Tachikawa H, Kimura R, Ishimaru Y, Kasai A, Maeda S.
Eur J Pharm Biopharm. 2012 May;81(1):64-73. doi: 10.1016/j.ejpb.2012.01.008.

Apelin deficiency accelerates the progression of amyotrophic lateral sclerosis.
Kasai A, Kinjo T, Ishihara R, Sakai I, Ishimaru Y, Yoshioka Y, Yamamuro A, Ishige K, Ito Y, Maeda S.
PLoS One. 2011;6(8):e23968. doi: 10.1371/journal.pone.0023968.

Caspase-4 directly activates caspase-9 in endoplasmic reticulum stress-induced apoptosis in SH-SY5Y cells.
Yamamuro A, Kishino T, Ohshima Y, Yoshioka Y, Kimura T, Kasai A, Maeda S.
J Pharmacol Sci. 2011;115(2):239-243. doi: 10.1254/jphs.10217sc.

Phenotypic Characterization of transgenic mice overexpressing neureglin-1.
Kato T, Kasai A, Mizuno M, Fengyi L, Shintani N, Maeda S, Yokoyama M, Ozaki M, Nawa H.
PLoS One. 2010 Dec 9;5(12):e14185. doi: 10.1371/journal.pone.0014185.

Apelin is a crucial factor for hypoxia-induced retinal angiogenesis.
Kasai A, Ishimaru Y, Kinjo T, Satooka T, Matsumoto N, Yoshioka Y, Yamamuro A, Gomi F, Shintani N, Baba A, Maeda S.
Arterioscler Thromb Vasc Biol. 2010 Nov;30(11):2182-7. doi: 10.1161/ATVBAHA.110.209775.

Nitric oxide inhibits lipopolysaccharide-induced inducible nitric oxide synthase expression and its own production through cGMP signaling pathway in murine microglia BV-2 cells.
Yoshioka Y, Takeda N, Yamamuro A, Kasai A, Maeda S.
J Pharmacol Sci. 2010;113(2):153-60. doi: 10.1254/jphs.10060fp.

Retardation of retinal vascular development in apelin-deficient mice.
Kasai A, Shintani N, Kato H, Matsuda S, Gomi F, Haba R, Hashimoto H, Kakuda M, Tano Y, Baba A.
Arterioscler Thromb Vasc Biol. 2008 Oct;28(10):1717-22. doi: 10.1161/ATVBAHA.108.163402.

Neuroprotective action of endogenous PACAP in cultured rat cortical neurons.
Shintani N, Suetake S, Hashimoto H, Koga K, Kasai A, Kawaguchi C, Morita Y, Hirose M, Sakai Y, Tomimoto S, Matsuda T, Baba A.
Regul Pept. 2005 Mar 15;126(1-2):123-8. doi: 10.1016/j.regpep.2004.08.014.

Apelin is a novel angiogenic factor in retinal endothelial cells.
Kasai A, Shintani N, Oda M, Kakuda M, Hashimoto H, Matsuda T, Hinuma S, Baba A.
Biochem Biophys Res Commun. 2004 Dec 10;325(2):395-400. doi: 10.1016/j.bbrc.2004.10.042.

PACAP activates Rac1 and synergizes with NGF to activate ERK1/2, thereby inducing neurite outgrowth in PC12 cells.
Sakai Y, Hashimoto H, Shintani N, Katoh H, Negishi M, Kawaguchi C, Kasai A, Baba A.
Brain Res Mol Brain Res. 2004 Apr 7;123(1-2):18-26. doi: 10.1016/j.molbrainres.2003.12.013.

Possible involvement of a cyclic AMP-dependent mechanism in PACAP-induced proliferation and ERK activation in astrocytes.
Hashimoto H, Kunugi A, Arakawa N, Shintani N, Fujita T, Kasai A, Kawaguchi C, Morita Y, Hirose M, Sakai Y, Baba A.
Biochem Biophys Res Commun. 2003 Nov 14;311(2):337-43. doi: 10.1016/j.bbrc.2003.10.005.