原著論文　Papers

2023
Sugimoto Y, *Masuda Y, Iwai S, Miyake Y, Kanao R, Masutani C. Novel mechanisms for the removal of strong replication-blocking
HMCES- and thiazolidine-DNA adducts in humans. Nucleic Acids Research, doi:10.1093/nar/gkad246
2022
Kanao R, Kawai H, Taniguchi T, Takata M, and *Masutani C. RFWD3 and translesion DNA polymerases contribute to PCNA modification–dependent DNA damage tolerance. Life Sci Alliance, 5, e202201584. doi: 10.26508/lsa.202201584. PMID: 35905994
Sonohara Y, Takatsuka R, Masutani C, Iwai S, *Kuraoka I. Acetaldehyde induces NER repairable mutagenic DNA lesions. Carcinogenesis, 43, 52-59 doi: 10.1093/carcin/bgab087. PMID: 34546339
2019
*Masuda Y, Saeki Y, Arai N, Kawai H, Kukimoto I, Tanaka K, Masutani C. (2019) Stepwise multipolyubiquitination of p53 by the E6AP-E6 ubiquitin ligase complex. J Biol Chem 294, 14860-14875 doi: 10.1074/jbc.RA119.008374. PMID: 31492752

*Masuda Y, Kanao R, Kawai H, Kukimoto I, Masutani C. (2019) Preferential digestion of PCNA-ubiquitin and p53-ubiquitin linkages by USP7 to remove polyubiquitin chains from substrates. J Biol Chem. 294, 4177-4187. doi: 10.1074/jbc.RA118.005167. PMID:30647135
2018
*Masuda Y, Mitsuyuki S, Kanao R, Hishiki A, Hashimoto H, Masutani C. (2018) Regulation of HLTF-mediated PCNA polyubiquitination by RFC and PCNA monoubiquitination levels determines choice of damage tolerance pathway. Nucleic Acids Res. 46, 11340-11356. doi: 10.1093/nar/gky943. PMID:30335157
2017
Sasatani M, Xi Y, Kajimura J, Kawamura T, Piao J, Masuda Y, Honda H, Kubo K, Mikamoto T, Watanabe H, Xu Y, Kawai H, Shimura T, Noda A, Hamasaki K, Kusunoki Y, Zaharieva E, *Kamiya K. (2017) Overexpression of Rev1 promotes the development of carcinogen-induced intestinal adenomas via accumulation of point mutation and suppression of apoptosis proportionally to the Rev1 expression level. Carcinogenesis 38, 570-578. doi: 10.1093/carcin/bgw208
2015
Kashiwaba S, Kanao R, Masuda Y, Matsuo-Kusumoto R, Hanaoka F, *Masutani C. (2015) USP7 Is a Suppressor of PCNA Ubiquitination and Oxidative-Stress-Induced Mutagenesis in Human Cells. Cell Rep. 13, 2072-2080 doi:10.1016/j.celrep.2015.11.014

Le HP, Masuda Y, Tsurimoto T, Maki S, Katayama T, *Furukohri A, Maki H.Short CCG repeat in huntingtin gene is an obstacle for replicative DNA polymerases, potentially hampering progression of replication fork.Genes Cell 20, 817-33. doi: 10.1111/gtc.12275

Masuda Y, Kanao R, Kaji K, Ohmori H, Hanaoka F, *Masutani C. Different types of interaction between PCNA and PIP boxes contribute to distinct cellular functions of Y-family DNA polymerases. Nucleic Acids Res. 43, 7898-7910. doi: 10.1093/nar/gkv712

Niimi A, Hopkins SR, Downs JA, *Masutani C. The BAH domain of BAF180 is required for PCNA ubiquitination. Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis 779, 16-23, doi:10.1016/j.mrfmmm.2015.06.006

Takahata C, Masuda Y, Takedachi A, Tanaka K, Iwai S, *Kuraoka I. Repair synthesis step involving ERCC1-XPF participates in DNA repair of the Top1-DNA damage complex. Carcinogenesis. pii: bgv078. doi: 10.1093/carcin/bgv078

Kanao R, Yokoi M, Ohkumo T, Sakurai Y, Dotsu K, Kura S, Nakatsu Y, Tsuzuki T, Masutani C, *Hanaoka F. UV-induced mutagenesis in epidermal cells of mice defective in DNA polymerase η and/or ι. DNA Repair 29, 139-146, doi:10.1016/j.dnarep.2015.02.006.

Kanao R, Masuda Y, Deguchi S, Yumoto-Sugimoto M, Hanaoka F, *Masutani C. Relevance of Simultaneous Mono-Ubiquitinations of Multiple Units of PCNA Homo-Trimers in DNA Damage Tolerance. PLoS One 10, e0118775. doi: 10.1371/journal.pone.0118775.
2014
Kamath-Loeb AS, Balakrishna S, Whittington D, Shen JC, Emond MJ, Okabe T, Masutani C, Hanaoka F, Nishimura S, *Loeb LA. Sphingosine: a modulator of human translesion DNA polymerase activity. J. Biol. Chem.289, 21663-21672, doi: 10.1074/jbc.M114.57024

Cao L, *Kawai H, Sasatani M, Iizuka D, Masuda Y, Inaba T, Suzuki K, Ootsuyama A, Umata T, Kamiya K, Suzuki F: A novel ATM/TP53/p21-mediated checkpoint only activated by chronic γ -irradiation. PLoS ONE 9: e104279, 2014.

Shibutani T, *Ito S, Toda M, Kanao R, Collins LB, Shibata M, Urabe M, Koseki H, Masuda Y, Swenberg JA, Masutani C, Hanaoka F, Iwai S, *Kuraoka I. Guanine- 5-carboxylcytosine base pairs mimic mismatches during DNA replication. Sci. Rep. 4, 5220, doi: 10.1038/srep05220.

Yamamoto J, Oyama T, Kunishi T, Masutani C, Hanaoka F, *Iwai S. A cyclobutane thymine-N4-methylcytosine dimer is resistant to hydrolysis but strongly blocks DNA synthesis. Nucleic Acids Res. 42, 2075-2084
2013
Arichi N, Yamamot J, Takahata C, Sano E, Masuda Y, Kuraoka I, *Iwai S. (2013) Strand breakage of a (6-4) photoproduct-containing DNA at neutral pH and its repair by the ERCC1-XPF protein complex. Org. Biomol. Chem. 11, 3526-3534

Tomida J, Itaya A, Shigechi T, Unno J, Uchida E, Ikura M, Masuda Y, Matsuda S, Adachi J, Kobayashi M, Meetei AR, Maehara Y, Yamamoto KI, Kamiya K, Matsuura A, Matsuda T, Ikura T, Ishiai M, *Takata M. (2013) A novel interplay between the Fanconi anemia core complex and ATR-ATRIP kinase during DNA cross-link repair. Nucleic Acids Res. 41, 6930-6941
2012
*Masuda Y, Suzuki M, Kawai H, Hishiki A, Hashimoto H, Masutani C, Hishida T, Suzuki F, Kamiya K. (2012) En bloc transfer of poly-ubiquitin chains to PCNA in vitro is mediated by two human E2-E3 pairs. Nucleic. Acids Res. 40, 10394-10407

*Masuda Y, Suzuki M, Kawai H, Suzuki, F, Kamiya, K. (2012) Asymmetric nature of two subunits of RAD18, a RING-type ubiquitin ligase E3, in the human RAD6A–RAD18 ternary complex. Nucleic Acids Res. 40, 1065-1076
2011
Yanagihara H, Kobayashi J, Tateishi S, Kato A, Matsuura S, Tauchi H, Yamada K, Takwzawa J, Sugasawa K, Masutani C, Hanaoka F, Weemaes CM, Mori T, Zou L, *Komatsu K. (2011) NBS1 recruits RAD18 via a RAD6-like domain and regulates Polη-dependent translesion DNA synthesis. Mol. Cell 43, 788-797

Pozo FM, Oda T, Sekimoto T, Murakumo Y, Masutani C, Hanaoka F, *Yamashita T. (2011) Molecular Chaperone Hsp90 Regulates REV1-Mediated Mutagenesis. Mol. Cell. Biol. 31, 3396-3409

Yamamoto J, Nishiguchi K, Manabe K, Masutani C, Hanaoka F, *Iwai S. (2011) Photosensitized [2 + 2] cycloaddition of N-acetylated cytosine affords stereoselective formation of cyclobutane pyrimidine dimer. Nucleic Acids Res. 39, 1165-1175
2010
Hirota K, Sonoda E, Kawamoto T, Motegi A, Masutani C, Hanaoka F, Szüts D, Iwai S, Sale JE, Lehmann A, *Takeda S. (2010) Simultaneous disruption of two DNA polymerases, Polη and Polζ, in avian DT40 cells unmasks the role of Polη in cellular response to various DNA lesions. PLoS Genetics 6, pii: e1001151

Kashiwagi S, Kuraoka I, Fujiwara Y, Hitomi K, Cheng QJ, Fuss JO, Shin DS, Masutani C, Tainer JA, Hanaoka F, *Iwai S. (2010) Characterization of a Y-family DNA polymerase eta from the eukaryotic themophile Alvinella pompejana. J. Nucleic Acids 2010, pii: 701472

Biertümpfel C, Zhao Y, Kondo Y, Ramón-Maiques S, Gregory M, Lee JY, Masutani C, Lehmann AR, *Hanaoka F, *Yang W. (2010) Structure and mechanism of human DNA polymerase η. Nature 46, 1044-1048

Sekimoto T, Oda T, Pozo FM, Murakumo Y, Masutani C, Hanaoka F, *Yamashita T. (2010) The molecular chaperone Hsp90 regulates accumulation of DNA polymerase η at replication stalling sites in UV-irradiated cells. Mol. Cell 37, 79-89

Chijiwa S, Masutani C, Hanaoka F, Iwai S, *Kuraoka I. (2010) Polymerization by DNA polymerase η is blocked by cis-diamminedichloroplatinum(II) 1,3-d(GpTpG) crosslink: Implications for cytotoxic effects in nucleotide excision repair-negative tumor cells. Carcinogenesis 31, 388-393

Katafuchi A, Sassa A, Niimi N, Gruz P, Fujimoto H, Masutani C, Hanaoka F, Ohta T, *Nohmi T. (2010) Critical amino acids involved in erroneous incorporation of oxidized nucleotides by human DNA polymerase η and κ. Nucleic Acids Res. 38, 859-867
2009
Kanao R, Hanaoka F, *Masutani C. (2009) A novel interaction between human DNA polymerase η and MutLα. Biochem. Biophys. Res. Commun. 389, 40-45

Fukuda H, Takamura-Enya T, Masuda Y, Nohmi T, Seki C, Kamiya K, Sugimura T, Masutani C, Hanaoka F, *Nakagama H. (2009) Translesional DNA synthesis through a C8-guanyl adduct of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) in vitro: REV1 inserts dC opposite the lesion and DNA polymerase κ potentially catalyzes extension reaction from the 3’-dC terminus. J. Biol. Chem. 284, 25585-25592

Akagi J, *Masutani C, Kataoka Y, Kan T, Ohashi E, Mori T, Ohmori H, Hanaoka F. (2009) Interaction with DNA polymerase η is required for nuclear accumulation of REV1 and suppression of spontaneous mutations in human cells. DNA Repair (Amst) 8, 585-599

Kimura T, Takeuchi T, Kumamoto-Yonezawa Y, Ohashi E, Ohmori H, Masutani C, Hanaoka F, Sugawara F, Yoshida H, *Mizushina Y. (2009) Penicilliols A and B, novel inhibitors specific to mammalian Y-family DNA polymerases. Bioorg. Med. Chem. 17, 1811-1816
2008
*Yasui M, Suenaga E, Koyama N, Masutani C, Hanaoka F, Gruz P, Shibutani S, Nohmi T, Hayashi M, Honma M. (2008) Miscoding property of 2’-deoxyinosine, a nitric oxide-derived DNA adduct, during translesion synthesis catalyzed by human DNA polymerases. J. Mol. Biol. 377, 1015-1023

Hidaka K, Yamada M, Kamiya H, Masutani C, Harashima H, Hanaoka F, *Nohmi T. (2008) Specificity of mutations induced by incorporation of oxidized dNTPs into DNA by human DNA polymerase η. DNA Repair (Amst) 7, 497-506
2007
Shiomi Y, Masutani C, Hanaoka F, Kimura H, *Tsurimoto T. (2007) A second PCNA loader complex, Ctf18-RFC, specifically stimulates DNA polymerase η activity. J. Biol. Chem. 282, 20906-20914

Satou K, Kasai H, Masutani C, Hanaoka F, Harashima H, Kamiya H. (2007) 2-Hydroxy-2'-deoxyadenosine 5'-triphosphate enhances A.T --> C.G mutations caused by 8-hydroxy-2'-deoxyguanosine 5'-triphosphate by suppressing its degradation upon replication in a HeLa extract. Biochemistry 46, 6639-6646

Masuda K, Ouchida R, Hikida M, Kurosaki T, Yokoi M, Masutani C, Seki M, Wood RD, Hanaoka F, O-Wang J. (2007) DNA polymerase η and θ function in the same genetic pathway to generate mutations at A/T during somatic hypermutation of Ig genes. J. Biol. Chem., 282, 17387-17394

Shimizu M, Gruz P, Kamiya H, Masutani C, Xu Y, Sugiyama H, Harashima H, Hanaoka F, Nohmi T. (2007) Efficient and erroneous incorporation of oxidized DNA precursors by human DNA polymerase η. Biochemistry 46, 5515-5522
2006
Ohkumo T, Kondo Y, Yokoi M, Tsukamoto T, Yamada A, Sugimoto T, Kanao R, Higashi Y, Kondoh H, Tatematsu M, Masutani C, *Hanaoka F. (2006) Ultraviolet B radiation induces epithelial tumors in mice lacking Polη and mesenchymal tumors in mice deficient for Polι. Mol. Cell. Biol. 26, 7696-7706

Yuasa SM, Masutani C, Hirano A, Cohn MA, Yamaizumi M, Nakatani Y, *Hanaoka F. (2006) A human DNA polymerase η complex containing Rad18, Rad6 and Rev1; proteomic analysis and targeting of the complex to the chromatin-bound fraction of cells undergoing replication fork arrest. Genes Cells 11, 731-744

Ohkumo T, Masutani C, Eki T, Hanaoka F. (2006) Deficiency of the Caenorhabditis elegans DNA polymerase η homologue increases sensitivity to UV radiation during germ-line development. Cell Struct. Funct. 31, 29-37
2005
Kawamoto T, Araki K, Sonoda E, Yamashita YM, Harada KK, Kikuchi K, Masutani C, Hanaoka F, Nozaki K, Hashimoto N, Takeda S. (2005) Dual roles for DNA polymerase η in homologous DNA recombination and translesion DNA synthesis. Mol. Cell 20, 793-79

Chiapperino D, Cai M, Sayer JM, Yagi H, Kroth H, Masutani C, Hanaoka F, Jerina DM, Cheh AM. (2005) Error-prone translesion synthesis by human DNA polymerase η on DNA containing deoxyadenosine adducts of 7.8-dihydroxy-9,10-epoxy-7,8,9,10-tetrahydrobenzo[α]pyrene. J. Biol. Chem. 280, 39684-39692

Nishi R, Okuda Y, Watanabe E, Mori T, Iwai S, Masutani C, Sugasawa K, Hanaoka F. (2005) Centrin 2 stimulates nucleotide excision repair by interacting with xeroderma pigmentosum group C protein. Mol. Cell. Biol. 25, 5664-5674

Martomo SA, Yang WW, Wersto RP, Ohkumo T, Kondo Y, Yokoi M, Masutani C, Hanaoka F, Gearhart PJ. (2005) Different mutationsignatures in DNA polymerase η- and MSH6-deficient mice suggest separate roles in antibody diversification. Proc. Natl. Acad. Sci. USA 102, 8656-8661
2004
Kusumoto R, Masutani C, Simmyo S, Iwai S, Hanaoka F. (2004) DNA binding properties of human DNA polymerase η: Implication for polymerase switching. Genes Cells 9, 1139-1150

Seki M, Masutani C, Yang LW, Schuffert A, Iwai S, Bahar I, Wood RD. (2004) High-efficiency bypass of DNA damage by human DNA polymerase Q. EMBO J. 23, 4484-4494

Ohashi E, Murakumo Y, Kanjo N, Akagi J, Masutani C, Hanaoka F, Ohmori H.(2004) Interaction of hREV1 with three human Y-family DNA polymerases. Genes Cells 9, 523-531

Suzuki N, Itoh S, Poon K, Masutani C, Hanaoka F, Ohmori H, Yoshizawa I, Shibutani S. (2004)Translesion synthesis past estrogen-derived DNA adducts by human DNA polymerasesηand k. Biochemistry 43, 6304-6311

Takasawa K, Masutani C, Hanaoka F, Iwai S. (2004) Chemical synthesis and translesion replication of a cis-syn cyclobutane thymine-uracil dimer. Nucleic Acids Res. 32, 1738-1745

Niimi A, Limsirichaikul S, Yoshida S, Iwai S, Masutani C, Hanaoka F, Kool ET, Nishiyama Y, Suzuki M. (2004) Palm mutants in DNA polymerases α andηalter DNA replication fidelity and translesion activity. Mol. Cell. Biol. 24, 2734-2746

McCulloch SD, Kokoska RJ, Masutani C, Iwai S, Hanaoka F, Kunkel TA. (2004) Preferential cis-syn thymine dimer bypass by DNA polymeraseηoccurs with biased fidelity. Nature 428, 97-10
2003
Bassett E, Vaisman A, Havener JM, Masutani C, Hanaoka F, Chaney SG. (2003) Efficiency of extension of mismatched primer termini across from cisplatin and oxaliplatin adducts by human DNA polymerases β andηin vitro. Biochemistry 42, 14197-14206

Higurashi M, Ohtsuki T, Inase A, Kusumoto R, Masutani C, Hanaoka F, Iwai S. (2003) Identification and characterization of an intermediate in the alkali degradation of (6-4) photoproduct-containing DNA. J. Biol. Chem. 278, 51968-51973

Jaloszynski P, Masutani C, Hanaoka F, Perwz AB, Nishimura S. (2003) 8-Hydroxyguanine in a mutational hotspot of c-Ha-ras gene causes misreplication, “action-at-a-distance” mutagenesis and inhibition of replication. Nucleic Acids Res. 31, 6085-6095

McDonald JP, Frank EG, Plosky BS, Rogozin IB, Masutani C, Hanaoka F, Woodgate R, Gearhart PJ. (2003) 129-derived strains of mice are deficient in DNA polymerase ι and have normal immunoglobulin hypermutation. J. Exp. Med. 198, 635-643

Shimizu M, Gruz P, Kamiya H, Kim SR, Pisani FM, Masutani C, Kanke Y, Harashima H, Hanaoka F, Nohmi T. (2003) Erroneous incorporation of oxidized DNA precursors by Y-family DNA polymerases. EMBO Rep. 4, 269-273
2002
Bassett E, Vaisman A, Tropea KA, McCall CM, Masutani C, Hanaoka F, Chaney SG. (2002) Frameshifts and deletions during in vitro translesion synthesis past Pt-DNA adducts by DNA polymerase β andη. DNA Repair 1, 1003-1016

Yamada A, Masutani C, Hanaoka F. (2002) Detection of reduced RNA synthesis in UV-irradiated Cockayne syndrome group B cells using an isolated nuclear system. Biochim. Biophys. Acta 1592, 129-134

Uchida A, Sugasawa K, Masutani C, Dohmae N, Araki M, Yokoi M, Ohkuma Y, Hanaoka F. (2002) The carboxy-terminal domain of the XPC protein plays a crucial role in nucleotide excision repair through interactions with transcription factor IIH. DNA Repair 1, 449-461

Kusumoto R, Masutani C, Iwai S, Hanaoka F. (2002) Translesion synthesis by human DNA polymeraseηacross thymine glycol lesions. Biochemistry, 41, 6090-6099

Chiapperino D, Kroth H, Kramarczuk IH, Sayer JM, Masutani C, Hanaoka F, Jerina DM, Cheh AM. (2002) Preferential misincorporation of purine nucleotides by human DNA polymeraseηopposite benzo[α]pyrene 7,8-diol 9,10-epoxide deoxyguanosine adducts. J. Biol. Chem. 277, 11765-11771

Broughton BC, Cordonnier A, Kleijer WJ, Jaspers NGJ., Fawcett H, Raams A, Garritsen VH, Stary A, Avril M-F, Boudsocq F, Masutani C, Hanaoka F, Fuchs RP, Sarasn A, Lehmann AR. (2002) Molecular analysis of mutations in DNA polymeraseηin xeroderma pigmentosum-variant patients. Proc. Natl. Acad. Sci. USA 99, 815-820
2001
Kuraoka I, Robins P, Masutani C, Hanaoka F, Gasparutto D, Cadet J, Wood RD, Lindahl T. (2001) Oxygen free-radical damage to DNA: translesion synthesis by human DNA polymeraseη and resistance to exonuclease action at cyclopurine deoxynucleoside residues. J. Biol. Chem. 276, 49283-49288

Matsuda T, Bebenek K, Masutani C, Rogozin IB, Hanaoka F, Kunkel TA. (2001) Error rate and specificity of human and murin DNA polymeraseη. J. Mol. Biol. 312, 335-346

Levine RL, Miller H, Grollman A, Ohashi E, Ohmori H, Masutani C, Hanaoka F, Moriya M. (2001) Translesion DNA synthesis catalyzed by human polηand pol κ across 1,N6-ethenodeoxyadenosine. J. Biol. Chem. 276, 18717-18721

Araki M, Masutani C, Takemura M, Uchida A, Sugasawa K, Kondo J, Ohkuma Y, Hanaoka F. (2001) Centrosome protein centrin 2/caltractin 1 is part of the xeroderma pigmentosum group C complex that initiates global genome nucleotide excision repair. J. Biol. Chem. 276, 18665-18672

Ishikawa T, Uematsu N, Mizukoshi T, Iwai S, Iwasaki H, Masutani C, Hanaoka F, Ueda R, Ohmori H, Todo T. (2001) Mutagenic and non-mutagenic bypass of DNA lesions by Drosophila DNA polymerases dpolη and dpolι. J. Biol. Chem. 276, 15155-15163

Ura K, Araki M, Saeki H, Masutani C, Ito T, Iwai S, Mizukoshi T, Kaneda Y, Hanaoka F. (2001) ATP-dependent chromatin remodeling facilitates nucleotide excision repair of UV-induced DNA lesions in synthetic dinucleosomes. EMBO J. 20, 2004-2014

Kusumoto R, Masutani C, Sugasawa K, Iwai S, Araki M, Uchida A, Mizukoshi T, Hanaoka F. (2001) Diversity of the damage recognition step in the global genomic nucleotide excision repair in vitro. Mutat. Res. 485, 219-227

Sugasawa K, Okamoto T, Shimizu Y, Masutani C, Iwai S, Hanaoka F. (2001) A multistep damage recognition mechanism for global genomic nucleotide excision repair. Genes Dev. 15, 507-521

Bebenek K, Matsuda T, Masutani C, Hanaoka F, Kunkel TA. (2001) Proofreading of DNA polymeraseη-dependent replication errors. J. Biol. Chem. 276: 2317-2320
2000
Yuasa M, Masutani C, Eki T, Hanaoka F. (2000) Genomic structure, chromosomal localization and identification of mutations in the xeroderma pigmentosum variant (XPV) gene. Oncogene 19, 4721-4728

Miao F, Bouziane M, Dammann R, Masutani C, Hanaoka F, Pfeifer G, O’Connor TR. (2000) 3-methyladenine-DNA glycosylase (MPG protein) interacts with human RAD23 proteins. J. Biol. Chem. 275, 28433-28438

Ohashi E, Ogi T, Kusumoto R, Iwai S, Masutani C, Hanaoka F, Ohmori H. (2000) Error-prone bypass of certain DNA lesions by the human DNA polymerase κ. Genes Dev. 14, 1589-1594

Yamada A, Masutani C, Iwai S, Hanaoka F. (2000) Complementation of defective translesion synthesis and ultraviolet light sensitivity in xeroderma pigmentosum variant cells by human and mouse DNA polymeraseη. Nucleic Acids Res. 28, 2473-2480

Masutani C, Kusumoto R, Iwai S, Hanaoka F. (2000) Mechanisms of accurate translesion synthesis by human DNA polymeraseη. EMBO J. 19, 3100-3109

Watanabe Y, Fujimoto H, Watanabe T, Maekawa T, Masutani C, Hanaoka F, Ohkuma Y. (2000) Modulation of TFIIH-associated kinase activity by complex formation and its relationship with CTD phosphorylation of RNA polymerase II. Genes Cells 5, 407-423

Matsuda T, Bebenek K, Masutani C, Hanaoka F, Kunkel TA. (2000) Low fidelity DNA synthesis by human DNA polymeraseη. Nature 404, 1011-1013

Vaisman A, Masutani C, Hanaoka F, Chaney SG. (2000) Efficient translesion replication past oxaliplatin and cisplatin GpG adducts by human DNA polymeraseη. Biochemistry 39, 4575-4580

Yokoi M, Masutani C, Maekawa T, Sugasawa K, Ohkuma Y, Hanaoka F. (2000) The xeroderma pigmentosum group C protein complex XPC-HR23B plays an important role in the recruitment of TFIIH to damaged DNA. J. Biol. Chem. 275, 9870-9875

Araki M, Masutani C, Maekawa T, Watanabe Y, Yamada A, Kusumoto R, Sakai D, Sugasawa K, Ohkuma Y, Hanaoka F. (2000) Reconstitution of damage DNA excision reaction from SV40 minichromosomes with purified nucleotide excision repair proteins. Mutat. Res. 459, 147-160
1999
Hiyama H, Yokoi M, Masutani C, Sugasawa K, Maekawa T, Tanaka K, Hoeijmakers JHJ, Hanaoka F. (1999) Interaction of hHR23 with S5a: The ubiquitin-like domain of hHR23 mediates interaction with S5a subunit of 26S proteasome. J. Biol. Chem. 274, 28019-28025

Fujiwara Y, Masutani C, Mizukoshi T, Kondo J, Hanaoka F, Iwai S. (1999) Characterization of DNA recognition by the human UV-damaged-DNA binding protein. J. Biol. Chem. 274, 20027-20033

Masutani C, Kusumoto R, Yamada A, Dohmae N, Yokoi M, Yuasa M, Araki M, Iwai S, Takio K, Hanaoka F. (1999) The XPV (xeroderma pigmentosum variant) gene encodes human DNA polymeraseη. Nature 399, 700-704

Masutani C, Araki M, Yamada A, Kusumoto R, Nogimori T, Maekawa T, Iwai S, Hanaoka F. (1999) Xeroderma pigmentosum variant (XP-V) correcting protein from HeLa cells has a thymine dimer bypass DNA polymerase activity. EMBO J. 18, 3491-3501

Iwai S, Mizukoshi T, Fujiwara Y, Masutani C, Hanaoka F, Hayakawa Y. (1999) Benzimidazolium triflate-activated synthesis of (6-4) photoproduct-containing oligonucleotides and its application. Nucleic Acids Res. 27, 2299-2303
1998以前
Sugasawa K, Ng JMY, Masutani C, Iwai S, van der Spek PJ, Eker APM, Hanaoka F, Bootsma D, Hoeijmakers JHJ. (1998) Xeroderma pigmentosum group C protein complex is the initiator of global genome nucleotide excision repair. Mol. Cell 2, 223-232

Kai M, Todo T, Wada M, Ryo H, Masutani C, Kobayashi H, Morioka H, Ohtsuka E, Hanaoka F, Sakaguchi K.(1998) A new Drosophila ultraviolet light-damaged DNA recognition endonuclease that selectively nicks a (6-4) photoproduct site. Biochim. Biophys. Acta 1397, 180-188

Sugasawa K, Ng JMY, Masutani C, Maekawa T, Uchida A, van der Spek PJ, Eker A, Rademakers S, Visser C, Aboussekhra A, Wood RD, Hanaoka F, Bootsma D, Hoeijmakers JHJ. (1997) Two human homologues of Rad23 are functionally interchangeable in complex formation and stimulation of XPC repair activity. Mol. Cell. Biol. 17, 6924-6931

Masutani C, Araki M, Sugasawa K, van der Spek PJ, Yamada A, Uchida A, Maekawa T, Bootsma D, Hoeijmakers JHJ, Hanaoka F. (1997) Identification and characterization of XPC-binding domain of hHR23B. Mol. Cell. Biol. 170, 6915-6923

Saijo M, Kuraoka I, Masutani C, Hanaoka F, Tanaka K. (1996) Sequential binding of DNA repair proteins RPA and ERCC1 to XPA in vitro. Nucleic Acids Res. 24, 4719-4724

Ito K, Asano M, Hughes P, Kohzaki H, Masutani C, Hanaoka F, Kerppola T, Curran T, Murakami Y, Ito Y. (1996) c-jun stimulates origin-dependent DNA unwinding by polyomavirus large T antigen. EMBO J. 15, 5636-5646

Sugasawa K, Masutani C, Uchida A, Maekawa T, van der Spek PJ, Bootsma D, Hoeijmakers JHJ, Hanaoka F. (1996) HHR23B, a human RAD23 homologue, stimulates XPC protein in nucleotide excision repair in vitro. Mol. Cell. Biol. 16, 4852-4861

van der Spek PJ, Eker A, Rademakers S, Visser C, Sugasawa K, Masutani C, Hanaoka F, Bootsma D, Hoeijmakers JHJ. (1996) XPC and human homologs of RAD23: intracellular localization and relationship to other nucleotide excision repair complexes. Nucleic Acids Res. 24, 2551-2559

Matsumoto K, Seki M, Masutani C, Tada S, Enomoto T, Ishimi Y. (1995) Stimulation of DNA synthesis by mouse DNA helicase B in a DNA replication system containing eukaryotic replication origins. Biochemistry 34, 7913-7922

Kamiya H, Miura H, M-Kamiya N, Ishikawa H, Sakaguchi T, Inoue H, Sasaki T, Masutani C, Hanaoka F, Nishimura S, Ohtsuka E. (1995) 8-Hydroxyadenine (7,8-dihydro-8-oxoadenine) induces misincorporation in in vitro DNA synthesis and mutations in NIH 3T3 cells. Nucleic Acids Res. 23, 2893-2899

Matsuda T, Saijo M, Kuraoka I, Kobayashi T, Nakatsu Y, Nagai A, Enjoji T, Masutani C, Sugasawa K, Hanaoka F, Yasui A, Tanaka K. (1995) DNA repair protein XPA binds replication protein A (RPA). J. Biol. Chem. 270, 4152-4157

Kamiya, H., M-Kamiya, N., Fujimuro, M., Kido, K., Inoue, H., Nishimura, S., Masutani, C., Hanaoka, F., Ohtsuka, E. (1995) Comparison of incorporation and extension of nucleotides in vitro opposite 8-hydroxyguanine (7,8 dihydro-8-oxoguanine) in hot spots of the c-Ha-ras gene. Jpn. J. Cancer Res. 86, 270-276

van der Spek, P.J., Smit, E.M.E., Beverloo, H.B., Sugasawa, K., Masutani, C., Hanaoka, F., Hoeijmakers, J.H.J., Hagemeijer, A. (1994) Chromosomal localization of three repair genes: the xeroderma pigmentosum group C gene and two human homologs of yeast RAD23. Genomics 23, 651-658

Masutani, C., Sugasawa, K., Yanagisawa, J., Sonoyama, T., Ui, M., Enomoto, T., Takio, K., Tanaka, K., van der Spek, P.J., Bootsma, D., Hoeijmakers, J.H.J., Hanaoka, F. (1994) Purification and cloning of a nucleotide excision repair complex involving the xeroderma pigmentosum group C protein and a human homolog of yeast RAD23. EMBO J. 13, 1831-1843

Kamiya, H., Murata, N., Murata, T., Iwai, S., Matsukage, A., Masutani, C., Hanaoka, F., Ohtsuka, E. (1993) Cyclobutane thymine dimers in a ras proto-oncogene hot spot activate the gene by point mutation. Nucleic Acids Res. 21, 2355-2361

Masutani, C., Sugasawa, K., Asahina, H., Tanaka, K., Hanaoka, F. (1993) Cell-free repair of UV-damaged simian virus 40 chromosomes in human cell extracts: II. Defective DNA repair synthesis by xeroderma pigmentosum cell extracts. J. Biol. Chem. 268, 9105-9109

Sugasawa, K., Masutani, C., Hanaoka, F. (1993) Cell-free repair of UV-damaged simian virus 40 chromosomes in human cell extracts: I. Development of a cell-free system detecting excision repair of UV-irradiated SV40 chromosomes in human cell extracts. J. Biol. Chem. 268, 9098-9104

Kamiya, H., Sakaguchi, T., Murata, N., Fujimuro, M., Miura, H., Ishikawa, H., Shimizu, M., Inoue, H., Nishimura, S., Matsukage, A., Masutani, C., Hanaoka, F., Ohtsuka, E. (1992) In vitro replication study of modified bases in ras sequences. Chem. Pharm. Bull. 40, 2792-2795

Kamiya, H., Suzuki, M., Komatsu, Y., Miura, H., Kikuchi, K., Sakaguchi, T., Murata, N., Masutani, C., Hanaoka, F., Ohtsuka, E. (1992) An abasic site analogue activates a c-Ha-ras gene by a point mutation at modified and adjacent positions. Nucleic Acids Res. 20: 4409-4415

Eki, T., Enomoto, T., Masutani, C., Miyajima, A., Takada, R., Murakami, Y., Ohno, T., Hanaoka, F., Ui, M. (1991) Mouse DNA primase plays the principal role in determination of permissiveness for polyomavirus DNA replication. J. Virol. 65, 4874-4881

Masutani, C., Enomoto, T., Suzuki, M., Hanaoka, F., Ui, M. (1990) DNA primase stimulatory factor from mouse FM3A cells has an RNase H activity. J. Biol. Chem. 265, 10210-1021

Suzuki, M., Enomoto, T., Masutani, C., Hanaoka, F., Yamada, M., Ui, M. (1989) DNA primase-DNA polymerase a assembly from mouse FM3A cells: purification of constituting enzymes, reconstitution, and analysis of RNA priming as coupled to DNA synthesis. J. Biol. Chem. 264, 10065-10071